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Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition

Dossus, Laure; Allen, Naomi; Kaaks, Rudolf; Bakken, Kjersti; Lund, Eiliv; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Clavel-Chapelon, Francoise and Fournier, Agnes, et al. (2010) In International Journal of Cancer 127(2). p.442-451
Abstract
Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity... (More)
Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis. (Less)
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publication status
published
subject
keywords
menopause, menarche, endometrial cancer, parity, oral contraceptive
in
International Journal of Cancer
volume
127
issue
2
pages
442 - 451
publisher
John Wiley & Sons
external identifiers
  • wos:000278919000020
  • scopus:77953707725
ISSN
0020-7136
DOI
10.1002/ijc.25050
language
English
LU publication?
yes
id
b491084a-ee7e-4366-a112-38b5bc3b7c6c (old id 1630418)
date added to LUP
2010-07-22 14:32:36
date last changed
2018-07-15 03:16:48
@article{b491084a-ee7e-4366-a112-38b5bc3b7c6c,
  abstract     = {Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.},
  author       = {Dossus, Laure and Allen, Naomi and Kaaks, Rudolf and Bakken, Kjersti and Lund, Eiliv and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Clavel-Chapelon, Francoise and Fournier, Agnes and Chabbert-Buffet, Nathalie and Boeing, Heiner and Schuetze, Madlen and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Lagiou, Pagona and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Vineis, Paolo and Mattiello, Amalia and Bueno-de-Mesquita, H. Bas and Onland-Moret, N. Charlotte and Peeters, Petra H. M. and Dumeaux, Vanessa and Redondo, Maria-Luisa and Duell, Eric and Sanchez-Cantalejo, Emilio and Arriola, Larraitz and Chirlaque, Maria-Dolores and Ardanaz, Eva and Manjer, Jonas and Borgquist, Signe and Lukanova, Annie and Lundin, Eva and Khaw, Kay-Tee and Wareham, Nicholas and Key, Tim and Chajes, Veronique and Rinaldi, Sabina and Slimani, Nadia and Mouw, Traci and Gallo, Valentina and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {menopause,menarche,endometrial cancer,parity,oral contraceptive},
  language     = {eng},
  number       = {2},
  pages        = {442--451},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.25050},
  volume       = {127},
  year         = {2010},
}