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Risk of transitional-cell carcinoma of the bladder in first- and second-generation immigrants to Sweden

Mousavi, Seyed Mohsen; Sundquist, Jan LU and Hemminki, Kari LU (2010) In European Journal of Cancer Prevention 19(4). p.275-279
Abstract
Environmental risk factors, particularly tobacco smoking, are important for transitional-cell carcinoma of the bladder. Studies in migrants may provide valuable insight into the environmental and genetic etiology of cancer. The nationwide Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs) for transitional-cell carcinoma among the immigrants compared with native Swedes. SIRs for lung cancer were also calculated as a proxy for smoking prevalence. Significantly decreased risks of bladder cancer were observed for male (SIR=0.89) and female (0.71) Finns and male East Asian (0.39) first-generation immigrants. Male immigrants from many countries showed increased risks, ranging from 1.18 to 2.29. Only female... (More)
Environmental risk factors, particularly tobacco smoking, are important for transitional-cell carcinoma of the bladder. Studies in migrants may provide valuable insight into the environmental and genetic etiology of cancer. The nationwide Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs) for transitional-cell carcinoma among the immigrants compared with native Swedes. SIRs for lung cancer were also calculated as a proxy for smoking prevalence. Significantly decreased risks of bladder cancer were observed for male (SIR=0.89) and female (0.71) Finns and male East Asian (0.39) first-generation immigrants. Male immigrants from many countries showed increased risks, ranging from 1.18 to 2.29. Only female immigrants from Denmark (1.40) and Norway (1.27) had increased risks. The risks for bladder and lung cancers correlated, except for Finnish and Iranian men. The sons of immigrants born in high-risk countries had an increased SIR (1.51) whereas the daughters of immigrants born in low-risk countries had a decreased risk (0.32). The risk in the second-generation immigrants born in Sweden was equal to that of natives. In conclusion, the observed bladder cancer risks in the first-generation immigrants, the changes in risks in the second-generation immigrants, and the covariation of the risk patterns of bladder and lung cancers suggested a main contribution by tobacco smoking. The exceptional patterns among the Finns and Iranians may point to the existence of modifying factors. The changes in incidence in second-generation immigrants, yet based on small case numbers, lend little support to the involvement of genetic factors. European Journal of Cancer Prevention 19:275-279 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
urinary bladder neoplasm, immigrants, transitional-cell carcinoma
in
European Journal of Cancer Prevention
volume
19
issue
4
pages
275 - 279
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000278372700004
  • scopus:77953528734
ISSN
1473-5709
DOI
10.1097/CEJ.0b013e3283387728
language
English
LU publication?
yes
id
d1479c51-dd68-4a54-888d-da0e14c9483b (old id 1632230)
date added to LUP
2010-07-22 12:53:56
date last changed
2018-05-29 09:20:01
@article{d1479c51-dd68-4a54-888d-da0e14c9483b,
  abstract     = {Environmental risk factors, particularly tobacco smoking, are important for transitional-cell carcinoma of the bladder. Studies in migrants may provide valuable insight into the environmental and genetic etiology of cancer. The nationwide Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs) for transitional-cell carcinoma among the immigrants compared with native Swedes. SIRs for lung cancer were also calculated as a proxy for smoking prevalence. Significantly decreased risks of bladder cancer were observed for male (SIR=0.89) and female (0.71) Finns and male East Asian (0.39) first-generation immigrants. Male immigrants from many countries showed increased risks, ranging from 1.18 to 2.29. Only female immigrants from Denmark (1.40) and Norway (1.27) had increased risks. The risks for bladder and lung cancers correlated, except for Finnish and Iranian men. The sons of immigrants born in high-risk countries had an increased SIR (1.51) whereas the daughters of immigrants born in low-risk countries had a decreased risk (0.32). The risk in the second-generation immigrants born in Sweden was equal to that of natives. In conclusion, the observed bladder cancer risks in the first-generation immigrants, the changes in risks in the second-generation immigrants, and the covariation of the risk patterns of bladder and lung cancers suggested a main contribution by tobacco smoking. The exceptional patterns among the Finns and Iranians may point to the existence of modifying factors. The changes in incidence in second-generation immigrants, yet based on small case numbers, lend little support to the involvement of genetic factors. European Journal of Cancer Prevention 19:275-279 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.},
  author       = {Mousavi, Seyed Mohsen and Sundquist, Jan and Hemminki, Kari},
  issn         = {1473-5709},
  keyword      = {urinary bladder neoplasm,immigrants,transitional-cell carcinoma},
  language     = {eng},
  number       = {4},
  pages        = {275--279},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Risk of transitional-cell carcinoma of the bladder in first- and second-generation immigrants to Sweden},
  url          = {http://dx.doi.org/10.1097/CEJ.0b013e3283387728},
  volume       = {19},
  year         = {2010},
}