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A new antitumour treatment combining radiation and electric pulses

Engström, P E LU ; Persson, B R LU ; Brun, A LU and Salford, L G LU (2001) In Anticancer research 21(3B). p.15-1809
Abstract

AIM: To investigate the antitumour effect of radiation in combination with electropermeabilization on subcutaneous rat glioma tumours.

MATERIALS AND METHODS: Sub-optimal radiation treatment was administered separately or in combination with electric pulses of high voltage to subcutaneous rat brain tumours. The treatment was repeated on four consecutive days and evaluated by TGD and microscopical examination. The tumours were stained for Factor VlII/von Willebrand Factor to investigate the effects on the tumour vasculature.

RESULTS: Radiation and electric pulses applied concomitantly resulted in a cure rate of 67% (tumour free >80 days after treatment). Radiation-treated animals showed progressive disease. Histological and... (More)

AIM: To investigate the antitumour effect of radiation in combination with electropermeabilization on subcutaneous rat glioma tumours.

MATERIALS AND METHODS: Sub-optimal radiation treatment was administered separately or in combination with electric pulses of high voltage to subcutaneous rat brain tumours. The treatment was repeated on four consecutive days and evaluated by TGD and microscopical examination. The tumours were stained for Factor VlII/von Willebrand Factor to investigate the effects on the tumour vasculature.

RESULTS: Radiation and electric pulses applied concomitantly resulted in a cure rate of 67% (tumour free >80 days after treatment). Radiation-treated animals showed progressive disease. Histological and immunohistochemical examination of electric impulse-treated tumours showed instant and severe deteriorating effects on tumour vasculature.

CONCLUSION: A distinct antitumour effect of the combined treatment of electric pulses and radiation treatment was observed. We believe that the tumouricidal effect arises from destruction of the tumour vasculature but also from DNA related damage from reactive oxygen formed by the electric pulses and the radiation treatment.

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organization
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type
Contribution to journal
publication status
published
keywords
Animals, Brain Neoplasms, Combined Modality Therapy, Electric Stimulation Therapy, Electricity, Factor VIII, Glioma, Immunohistochemistry, Male, Neoplasms, Rats, Rats, Inbred F344, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Anticancer research
volume
21
issue
3B
pages
7 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:0034903724
ISSN
0250-7005
language
English
LU publication?
yes
id
164132e2-4bdd-4417-b508-3f601bd3a385
date added to LUP
2017-04-05 14:21:46
date last changed
2018-10-03 10:12:02
@article{164132e2-4bdd-4417-b508-3f601bd3a385,
  abstract     = {<p>AIM: To investigate the antitumour effect of radiation in combination with electropermeabilization on subcutaneous rat glioma tumours.</p><p>MATERIALS AND METHODS: Sub-optimal radiation treatment was administered separately or in combination with electric pulses of high voltage to subcutaneous rat brain tumours. The treatment was repeated on four consecutive days and evaluated by TGD and microscopical examination. The tumours were stained for Factor VlII/von Willebrand Factor to investigate the effects on the tumour vasculature.</p><p>RESULTS: Radiation and electric pulses applied concomitantly resulted in a cure rate of 67% (tumour free &gt;80 days after treatment). Radiation-treated animals showed progressive disease. Histological and immunohistochemical examination of electric impulse-treated tumours showed instant and severe deteriorating effects on tumour vasculature.</p><p>CONCLUSION: A distinct antitumour effect of the combined treatment of electric pulses and radiation treatment was observed. We believe that the tumouricidal effect arises from destruction of the tumour vasculature but also from DNA related damage from reactive oxygen formed by the electric pulses and the radiation treatment.</p>},
  author       = {Engström, P E and Persson, B R and Brun, A and Salford, L G},
  issn         = {0250-7005},
  keyword      = {Animals,Brain Neoplasms,Combined Modality Therapy,Electric Stimulation Therapy,Electricity,Factor VIII,Glioma,Immunohistochemistry,Male,Neoplasms,Rats,Rats, Inbred F344,Time Factors,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {08},
  number       = {3B},
  pages        = {15--1809},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {A new antitumour treatment combining radiation and electric pulses},
  volume       = {21},
  year         = {2001},
}