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Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.

Lenora, Janaka; Åkesson, Kristina LU and Gerdhem, Paul LU (2010) In Journal of Clinical Densitometry 13(4). p.407-412
Abstract
Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009... (More)
Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Duel energy x-ray absorptiometry, longitudinal follow-up, least significant change, elderly individuals, precision error.
in
Journal of Clinical Densitometry
volume
13
issue
4
pages
407 - 412
publisher
Elsevier
external identifiers
  • wos:000283892400012
  • pmid:20605500
  • scopus:77958478634
ISSN
1094-6950
DOI
10.1016/j.jocd.2010.04.004
language
English
LU publication?
yes
id
19da6022-d8f5-4ac0-b6e6-96a22124735c (old id 1645281)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20605500?dopt=Abstract
date added to LUP
2010-08-02 10:32:43
date last changed
2018-05-29 09:31:15
@article{19da6022-d8f5-4ac0-b6e6-96a22124735c,
  abstract     = {Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons.},
  author       = {Lenora, Janaka and Åkesson, Kristina and Gerdhem, Paul},
  issn         = {1094-6950},
  keyword      = {Duel energy x-ray absorptiometry,longitudinal follow-up,least significant change,elderly individuals,precision error.},
  language     = {eng},
  number       = {4},
  pages        = {407--412},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Densitometry},
  title        = {Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.},
  url          = {http://dx.doi.org/10.1016/j.jocd.2010.04.004},
  volume       = {13},
  year         = {2010},
}