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Is aqueductal stroke volume, measured with cine phase-contrast magnetic resonance imaging scans useful in predicting outcome of shunt surgery in suspected normal pressure hydrocephalus?

Kahlon, Babar LU ; Annertz, Mårten LU ; Ståhlberg, Freddy LU and Rehncrona, Stig LU (2007) In Neurosurgery 60(1). p.124-129
Abstract
OBJECTIVE: To evaluate clinical usefulness of cerebrospinal fluid stroke volume (SV) assessed in the cerebral aqueduct, via cine phase-contrast magnetic resonance imaging, for predicting outcome after shunt surgery in suspected normal pressure hydrocephalus. METHODS: Thirty-eight patients with suspected normal pressure hydrocephalus were included. SV was assessed using cine phase-contrast magnetic resonance imaging, and kept blinded until postoperative follow-up after 7 +/- 5.8 months (mean the results were standard deviation). Selection to surgery was based on a positive lumbar infusion test or cerebrospinal fluid tap test, and outcome was evaluated with objective tests. RESULTS: Six patients were excluded from SV measurements because of... (More)
OBJECTIVE: To evaluate clinical usefulness of cerebrospinal fluid stroke volume (SV) assessed in the cerebral aqueduct, via cine phase-contrast magnetic resonance imaging, for predicting outcome after shunt surgery in suspected normal pressure hydrocephalus. METHODS: Thirty-eight patients with suspected normal pressure hydrocephalus were included. SV was assessed using cine phase-contrast magnetic resonance imaging, and kept blinded until postoperative follow-up after 7 +/- 5.8 months (mean the results were standard deviation). Selection to surgery was based on a positive lumbar infusion test or cerebrospinal fluid tap test, and outcome was evaluated with objective tests. RESULTS: Six patients were excluded from SV measurements because of technical difficulties. Eight patients were not operated (negative lumbar infusion test and cerebrospinal fluid tap test). SV in the not operated patients (mean, 66 +/- 53 mu l) did not differ from the operated patients (95 +/- 78 mu l; P = 0.335). Operated patients showed statistically significant improvements in walk (P = 0.020), reaction time (P = 0.006), and memory (P = 0.001) tests. Patients were divided into three groups according to SV range: low (0-50 mu l), middle (51 - 100 mu l), and high (> 100 mu l). No statistically significant (P > 0.05) improvements in any of the objective tests were found in any of the SV the different SV ranges. The numbers of individually improved patients were similar in ranges: six out of seven in the low, nine out of nine in the middle, and five out of eight in the high range. Weak correlations were found between SV and the initial pulse,amplitude (R-s = 0.043; P = 0.014) as well as the plateau pulse amplitude (R-s = 0.043; P = 4) as measured with the lumbar infusion test. CONCLUSION: The data from this Study show no evidence that cine phase-contrast magnetic resonance imaging measurements of SV in the cerebral aqueduct are useful for selecting patients with normal pressure hydrocephalus symptoms to shunt surgery. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurosurgery
volume
60
issue
1
pages
124 - 129
publisher
Congress of Neurological Surgeons
external identifiers
  • wos:000243421400024
  • scopus:33846250007
ISSN
0148-396X
DOI
10.1227/01.NEU.0000249208.04344.A3
language
English
LU publication?
yes
id
53fada63-7b0f-45fa-a43b-cbeff6a8a25a (old id 164863)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17228260&dopt=Abstract
date added to LUP
2007-07-16 09:47:42
date last changed
2017-10-01 04:43:02
@article{53fada63-7b0f-45fa-a43b-cbeff6a8a25a,
  abstract     = {OBJECTIVE: To evaluate clinical usefulness of cerebrospinal fluid stroke volume (SV) assessed in the cerebral aqueduct, via cine phase-contrast magnetic resonance imaging, for predicting outcome after shunt surgery in suspected normal pressure hydrocephalus. METHODS: Thirty-eight patients with suspected normal pressure hydrocephalus were included. SV was assessed using cine phase-contrast magnetic resonance imaging, and kept blinded until postoperative follow-up after 7 +/- 5.8 months (mean the results were standard deviation). Selection to surgery was based on a positive lumbar infusion test or cerebrospinal fluid tap test, and outcome was evaluated with objective tests. RESULTS: Six patients were excluded from SV measurements because of technical difficulties. Eight patients were not operated (negative lumbar infusion test and cerebrospinal fluid tap test). SV in the not operated patients (mean, 66 +/- 53 mu l) did not differ from the operated patients (95 +/- 78 mu l; P = 0.335). Operated patients showed statistically significant improvements in walk (P = 0.020), reaction time (P = 0.006), and memory (P = 0.001) tests. Patients were divided into three groups according to SV range: low (0-50 mu l), middle (51 - 100 mu l), and high (> 100 mu l). No statistically significant (P > 0.05) improvements in any of the objective tests were found in any of the SV the different SV ranges. The numbers of individually improved patients were similar in ranges: six out of seven in the low, nine out of nine in the middle, and five out of eight in the high range. Weak correlations were found between SV and the initial pulse,amplitude (R-s = 0.043; P = 0.014) as well as the plateau pulse amplitude (R-s = 0.043; P = 4) as measured with the lumbar infusion test. CONCLUSION: The data from this Study show no evidence that cine phase-contrast magnetic resonance imaging measurements of SV in the cerebral aqueduct are useful for selecting patients with normal pressure hydrocephalus symptoms to shunt surgery.},
  author       = {Kahlon, Babar and Annertz, Mårten and Ståhlberg, Freddy and Rehncrona, Stig},
  issn         = {0148-396X},
  language     = {eng},
  number       = {1},
  pages        = {124--129},
  publisher    = {Congress of Neurological Surgeons},
  series       = {Neurosurgery},
  title        = {Is aqueductal stroke volume, measured with cine phase-contrast magnetic resonance imaging scans useful in predicting outcome of shunt surgery in suspected normal pressure hydrocephalus?},
  url          = {http://dx.doi.org/10.1227/01.NEU.0000249208.04344.A3},
  volume       = {60},
  year         = {2007},
}