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Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

Oknianska, Alina LU ; Zmuda-Trzebiatowska, Emilia LU ; Manganiello, Vincent and Degerman, Eva LU (2007) In Biochemical and Biophysical Research Communications 353(4). p.1080-1085
Abstract
Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphatidylinositol 3-kinase-dependent manner whereas long-term treatment with P-adrenergic agonists induced down-regulation of PDE3B and up-regulation of PDE4D. Thus, PDE3B and PDE4D can be added to the list of genes regulated by insulin and cAMP-increasing hormones. Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin... (More)
Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphatidylinositol 3-kinase-dependent manner whereas long-term treatment with P-adrenergic agonists induced down-regulation of PDE3B and up-regulation of PDE4D. Thus, PDE3B and PDE4D can be added to the list of genes regulated by insulin and cAMP-increasing hormones. Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. (c) 2006 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phosphodiesterase 3B, phosphodiesterase 4, adipocyte, insulin, isoproterenol
in
Biochemical and Biophysical Research Communications
volume
353
issue
4
pages
1080 - 1085
publisher
Elsevier
external identifiers
  • wos:000243859600039
  • scopus:33846184759
ISSN
1090-2104
DOI
10.1016/j.bbrc.2006.12.141
language
English
LU publication?
yes
id
306a9b93-736e-4804-9a00-f39296b49763 (old id 165180)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17198676&dopt=Abstract
date added to LUP
2007-07-18 13:57:40
date last changed
2017-08-27 05:27:17
@article{306a9b93-736e-4804-9a00-f39296b49763,
  abstract     = {Phosphodiesterase 3B (PDE3B), is known to play an important role in acute insulin and cAMP-mediated regulation of lipid metabolism, and PDE4 are the main PDE types expressed in adipocytes. Here, we show that members of all PDE4 isoforms are expressed in 3T3-L1 and primary mouse adipocytes. Long-term treatment of 3T3-L1 adipocytes with insulin induced up-regulation of PDE3B and PDE4D in a phosphatidylinositol 3-kinase-dependent manner whereas long-term treatment with P-adrenergic agonists induced down-regulation of PDE3B and up-regulation of PDE4D. Thus, PDE3B and PDE4D can be added to the list of genes regulated by insulin and cAMP-increasing hormones. Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. (c) 2006 Elsevier Inc. All rights reserved.},
  author       = {Oknianska, Alina and Zmuda-Trzebiatowska, Emilia and Manganiello, Vincent and Degerman, Eva},
  issn         = {1090-2104},
  keyword      = {phosphodiesterase 3B,phosphodiesterase 4,adipocyte,insulin,isoproterenol},
  language     = {eng},
  number       = {4},
  pages        = {1080--1085},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2006.12.141},
  volume       = {353},
  year         = {2007},
}