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Age-Specific Risk of Incident Prostate Cancer and Risk of Death from Prostate Cancer Defined by the Number of Affected Family Members

Brandt, Andreas ; Bermejo, Justo Lorenzo ; Sundquist, Jan LU and Hemminki, Kari LU (2010) In European Urology 58(2). p.275-280
Abstract
Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. Design, setting, and participants: The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial. Measurements: The age-specific hazard ratios (HRs) of... (More)
Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. Design, setting, and participants: The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial. Measurements: The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers. Results and limitations: The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men <65 yr of age with three affected brothers (HR: approximately 23) and the lowest for men between 65 and 74 yr of age with an affected father (HR: approximately 1.8). The HRs increased with decreasing paternal or fraternal diagnostic age. The pattern of the risk of death from familial PCa was similar to the incidence data. Conclusions: The present results should guide clinical counselling and demonstrate the vast increases in risk when multiple first-degree relatives are affected. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer mortality, Prostate, Familial risk, Prostate cancer, Familial prostate cancer, Population-based studies
in
European Urology
volume
58
issue
2
pages
275 - 280
publisher
Elsevier
external identifiers
  • wos:000279745100022
  • scopus:77955309014
  • pmid:20171779
ISSN
1873-7560
DOI
10.1016/j.eururo.2010.02.002
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Family Medicine (013241010), Psychiatry/Primary Care/Public Health (013240500)
id
b5bab720-b6f0-44c1-8678-13304b99eada (old id 1657486)
date added to LUP
2016-04-01 14:15:19
date last changed
2022-04-14 08:53:15
@article{b5bab720-b6f0-44c1-8678-13304b99eada,
  abstract     = {{Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. Design, setting, and participants: The nationwide Swedish Family-Cancer Database includes a record of &gt;11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (&gt;3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial. Measurements: The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers. Results and limitations: The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men &lt;65 yr of age with three affected brothers (HR: approximately 23) and the lowest for men between 65 and 74 yr of age with an affected father (HR: approximately 1.8). The HRs increased with decreasing paternal or fraternal diagnostic age. The pattern of the risk of death from familial PCa was similar to the incidence data. Conclusions: The present results should guide clinical counselling and demonstrate the vast increases in risk when multiple first-degree relatives are affected. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.}},
  author       = {{Brandt, Andreas and Bermejo, Justo Lorenzo and Sundquist, Jan and Hemminki, Kari}},
  issn         = {{1873-7560}},
  keywords     = {{cancer mortality; Prostate; Familial risk; Prostate cancer; Familial prostate cancer; Population-based studies}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{275--280}},
  publisher    = {{Elsevier}},
  series       = {{European Urology}},
  title        = {{Age-Specific Risk of Incident Prostate Cancer and Risk of Death from Prostate Cancer Defined by the Number of Affected Family Members}},
  url          = {{http://dx.doi.org/10.1016/j.eururo.2010.02.002}},
  doi          = {{10.1016/j.eururo.2010.02.002}},
  volume       = {{58}},
  year         = {{2010}},
}