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Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer

Wegiel, Barbara LU ; Evans Axelsson, Susan LU ; Hellsten, Rebecka LU ; Otterbein, L. E.; Bjartell, Anders LU and Persson, J. L. (2010) In Current Cancer Drug Targets 10(4). p.392-401
Abstract
Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in... (More)
Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the development of hormone-independent/castration-resistant prostate cancer. In addition, we also discussed the recent findings on signatures of gene expression during prostate cancer progression. Our overviews on the novel findings will help to gain better understanding of the complexity of molecular mechanisms that may play an essential role for the development of castration-resistant and metastatic prostate cancer. It will also shed light on the identifying specific targets and design effective therapeutic drug candidates. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
castration, molecular pathways, Prostate cancer, androgen receptor, resistance
in
Current Cancer Drug Targets
volume
10
issue
4
pages
392 - 401
publisher
Bentham Science Publishers
external identifiers
  • wos:000279868900004
  • scopus:77953682204
ISSN
1873-5576
language
English
LU publication?
yes
id
67835a40-ecde-45bc-b5b0-a27d1616ba0a (old id 1657523)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20384583
date added to LUP
2010-08-31 12:53:08
date last changed
2018-05-29 10:40:14
@article{67835a40-ecde-45bc-b5b0-a27d1616ba0a,
  abstract     = {Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumor cell invasion and metastasis in prostate cancer. We specifically presented the most recent findings on the role of multiple cellular signaling pathways including androgen receptor (AR), mitogen-activated protein kinases (MAPK), Akt, transforming growth factor beta (TGF beta), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the development of hormone-independent/castration-resistant prostate cancer. In addition, we also discussed the recent findings on signatures of gene expression during prostate cancer progression. Our overviews on the novel findings will help to gain better understanding of the complexity of molecular mechanisms that may play an essential role for the development of castration-resistant and metastatic prostate cancer. It will also shed light on the identifying specific targets and design effective therapeutic drug candidates.},
  author       = {Wegiel, Barbara and Evans Axelsson, Susan and Hellsten, Rebecka and Otterbein, L. E. and Bjartell, Anders and Persson, J. L.},
  issn         = {1873-5576},
  keyword      = {castration,molecular pathways,Prostate cancer,androgen receptor,resistance},
  language     = {eng},
  number       = {4},
  pages        = {392--401},
  publisher    = {Bentham Science Publishers},
  series       = {Current Cancer Drug Targets},
  title        = {Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer},
  volume       = {10},
  year         = {2010},
}