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Photodynamic therapy: superficial and interstitial illumination.

Svanberg, Katarina LU ; Bendsöe, Niels LU ; Axelsson, Johan LU ; Andersson-Engels, Stefan LU and Svanberg, Sune LU (2010) In Journal of Biomedical Optics 15(4).
Abstract
Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial... (More)
Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biomedical Optics
volume
15
issue
4
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000281335400013
  • pmid:20799780
  • scopus:79952199883
ISSN
1083-3668
DOI
10.1117/1.3466579
language
English
LU publication?
yes
id
a01760d1-bc5a-4ff9-828f-bbfce764ec4c (old id 1664970)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20799780?dopt=Abstract
date added to LUP
2010-09-03 09:19:09
date last changed
2018-05-29 12:07:05
@article{a01760d1-bc5a-4ff9-828f-bbfce764ec4c,
  abstract     = {Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented.},
  articleno    = {041502},
  author       = {Svanberg, Katarina and Bendsöe, Niels and Axelsson, Johan and Andersson-Engels, Stefan and Svanberg, Sune},
  issn         = {1083-3668},
  language     = {eng},
  number       = {4},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Photodynamic therapy: superficial and interstitial illumination.},
  url          = {http://dx.doi.org/10.1117/1.3466579},
  volume       = {15},
  year         = {2010},
}