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Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension.

Bengtsson Boström, Kristina LU ; Hedner, Jan; Melander, Olle LU ; Grote, Ludger; Gullberg, Bo LU ; Råstam, Lennart LU ; Groop, Leif LU and Lindblad, Ulf LU (2007) In Journal of Hypertension 25(4). p.779-783
Abstract
Objective Obstructive sleep apnoea (OSA) confers a risk of hypertension and cardiovascular complications. Both the renin-angiotensin-aldosterone system and OSA are important determinants of blood pressure, but it is not fully known how they interact. The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension. Design A community-based, case-control design with hypertensive patients in primary care (n =157) and normotensive population controls (n =181). Methods All subjects underwent ambulatory polysomnography during one night. OSA was defined by a minimum of 10 apnoea/hypopnoea events per hour. Office blood... (More)
Objective Obstructive sleep apnoea (OSA) confers a risk of hypertension and cardiovascular complications. Both the renin-angiotensin-aldosterone system and OSA are important determinants of blood pressure, but it is not fully known how they interact. The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension. Design A community-based, case-control design with hypertensive patients in primary care (n =157) and normotensive population controls (n =181). Methods All subjects underwent ambulatory polysomnography during one night. OSA was defined by a minimum of 10 apnoea/hypopnoea events per hour. Office blood pressure was measured and hypertension status was assessed. The genotypes were determined using polymerase chain reaction. Results An interaction analysis including sex, ACE I/D polymorphism (DD and ID versus II), and OSA identified a significant interaction between OSA and the ACE I/D f polymorphism: odds ratio (OR) 6.3, 95% confidence interval (Cl) 1.8-22.5, P= 0.004 as well as between OSA and sex: OR 3.3, 95% Cl 1.1-9.6, P= 0.033. OSA was significantly associated with hypertension in men but not in women. Conclusion The interaction between the ACE gene I/D polymorphism and OSA appears to be an important mechanism in the development of hypertension, particularly in men. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
25
issue
4
pages
779 - 783
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000245312700008
  • scopus:33947112891
ISSN
1473-5598
DOI
10.1097/HJH.0b013e328017f6d5
language
English
LU publication?
yes
id
702cdcf9-6cff-4f05-a3e0-b665ca5dc12d (old id 166677)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17351369&dopt=Abstract
date added to LUP
2007-07-16 11:26:08
date last changed
2017-11-05 04:37:25
@article{702cdcf9-6cff-4f05-a3e0-b665ca5dc12d,
  abstract     = {Objective Obstructive sleep apnoea (OSA) confers a risk of hypertension and cardiovascular complications. Both the renin-angiotensin-aldosterone system and OSA are important determinants of blood pressure, but it is not fully known how they interact. The aim of this study was to explore the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and OSA in the association with hypertension. Design A community-based, case-control design with hypertensive patients in primary care (n =157) and normotensive population controls (n =181). Methods All subjects underwent ambulatory polysomnography during one night. OSA was defined by a minimum of 10 apnoea/hypopnoea events per hour. Office blood pressure was measured and hypertension status was assessed. The genotypes were determined using polymerase chain reaction. Results An interaction analysis including sex, ACE I/D polymorphism (DD and ID versus II), and OSA identified a significant interaction between OSA and the ACE I/D f polymorphism: odds ratio (OR) 6.3, 95% confidence interval (Cl) 1.8-22.5, P= 0.004 as well as between OSA and sex: OR 3.3, 95% Cl 1.1-9.6, P= 0.033. OSA was significantly associated with hypertension in men but not in women. Conclusion The interaction between the ACE gene I/D polymorphism and OSA appears to be an important mechanism in the development of hypertension, particularly in men.},
  author       = {Bengtsson Boström, Kristina and Hedner, Jan and Melander, Olle and Grote, Ludger and Gullberg, Bo and Råstam, Lennart and Groop, Leif and Lindblad, Ulf},
  issn         = {1473-5598},
  language     = {eng},
  number       = {4},
  pages        = {779--783},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328017f6d5},
  volume       = {25},
  year         = {2007},
}