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Inflammation at birth and the insulin-like growth factor system in very preterm infants.

Pupp, Ingrid LU ; Hellström-Westas, Lena LU ; Cilio, Corrado LU ; Andersson, S; Fellman, Vineta LU and Ley, David LU (2007) In Acta Pædiatrica 96(6). p.830-836
Abstract
Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA.... (More)
Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA. Results: In cord blood of infants appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were associated with lower IGF-I (r = -0.38, p = 0.008 and r = -0.36, p = 0.014). Higher levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of lpIGFBP-1 (r = 0.54, p < 0.001, r = 0.50, p < 0.001 and r = 0.13, p = 0.012, respectively) and hpIGFBP-1 (r = 0.55, p < 0.001, r = 0.45, p = 0.002 and r = 0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, respectively). Conclusion: Pro-inflammation at birth is associated with changes in the IGF-system. This may be of importance for development of brain damage in preterm infants. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
foetal inflammation, insulin-like growth factor, brain damage, cytokine, I, preterm
in
Acta Pædiatrica
volume
96
issue
6
pages
830 - 836
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000246789600012
  • scopus:34249818501
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2007.00276.x
language
English
LU publication?
yes
id
d62799fb-662d-4daa-8a77-9ef1cfa7010a (old id 167319)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17465986&dopt=Abstract
date added to LUP
2007-07-23 10:42:18
date last changed
2017-10-22 04:43:28
@article{d62799fb-662d-4daa-8a77-9ef1cfa7010a,
  abstract     = {Background: Foetal inflammation is associated with an increased risk of brain damage in preterm infants whereas IGF-I is essential for cerebral development and exhibits anti-apoptotic properties. Aim: To assess levels of IGF-I and IGF binding proteins at very preterm birth and to evaluate their relationship with foetal pro-inflammation and cerebral damage. Methods: Levels of IGF-I, IGF binding protein 3 (IGFBP-3), high- (hp) and low-phosphorylated (lp) IGFBP-1 in cord blood and neonatal blood at 72 h after delivery were analysed in relation to levels of cytokines and cerebral damage as detected by ultrasound in 74 inborn infants [mean gestational age (GA) 27.1 weeks]. Evaluation was performed separately according to birth weight for GA. Results: In cord blood of infants appropriate for gestational age (AGA) higher levels of IL-6 and IL-8 were associated with lower IGF-I (r = -0.38, p = 0.008 and r = -0.36, p = 0.014). Higher levels of IL-6, IL-8 and TNF-alpha were associated with both higher levels of lpIGFBP-1 (r = 0.54, p &lt; 0.001, r = 0.50, p &lt; 0.001 and r = 0.13, p = 0.012, respectively) and hpIGFBP-1 (r = 0.55, p &lt; 0.001, r = 0.45, p = 0.002 and r = 0.32, p = 0.026, respectively). Infants with intraventricular haemorrhage grade III (n = 5) had higher levels of lp/hpIGFBP-1 in cord blood (p = 0.001 and 0.002, respectively). Conclusion: Pro-inflammation at birth is associated with changes in the IGF-system. This may be of importance for development of brain damage in preterm infants.},
  author       = {Pupp, Ingrid and Hellström-Westas, Lena and Cilio, Corrado and Andersson, S and Fellman, Vineta and Ley, David},
  issn         = {1651-2227},
  keyword      = {foetal inflammation,insulin-like growth factor,brain damage,cytokine,I,preterm},
  language     = {eng},
  number       = {6},
  pages        = {830--836},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Inflammation at birth and the insulin-like growth factor system in very preterm infants.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2007.00276.x},
  volume       = {96},
  year         = {2007},
}