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Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.

Larsson, Helena LU ; Lynch, Kristian LU ; Lernmark, Barbro LU ; Hansson, Gertie LU ; Lernmark, Åke LU ; Ivarsson, Sten LU ; , and Carlsson, Annelie LU (2007) In Diabetologia 50(6). p.1161-1169
Abstract
Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane... (More)
Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane (DiPiS) study. Mothers reported gestational infections when the child was 2 months old. Results Fever or gastroenteritis during pregnancy was reported by 2,848/19,756 mothers (14%); 339 in more than one trimester. Children whose mothers reported infections had increased risk of HrBW (p=0.0003), particularly in the absence of cord blood islet autoantibodies (interaction between HrBW, islet autoantibodies and infections, p=0.0005). The effect on HrBW by high-risk HLA-DQ2/8 was aggravated by infections in more than one trimester (odds ratio [OR]=5.24; p=0.003) (interaction; p=0.022). When infections were reported, cord blood islet autoantibodies decreased HrBW (OR=0.34; p=0.0002). Conclusions/intrepretation This study revealed that: (1) gestational fever, gastroenteritis, or both, increased the risk of HrBW; (2) cord blood islet autoantibodies decreased the risk of HrBW only in combination with infections; and (3) infections aggravated the association between HLA-DQ2/8 and HrBW. These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IA-2 autoantibodies, gestational, infections, HLA, GAD65 autoantibodies, gastroenteritis, birthweight, fever, type 1 diabetes, islet autoantibodies, autoantibodies, insulin
in
Diabetologia
volume
50
issue
6
pages
1161 - 1169
publisher
Springer Verlag
external identifiers
  • wos:000246271600007
  • scopus:34247874558
ISSN
1432-0428
DOI
10.1007/s00125-007-0648-6
language
English
LU publication?
yes
id
be554eb5-29d4-4f72-8fb0-dccb150a78ab (old id 167813)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17406854&dopt=Abstract
date added to LUP
2007-07-25 09:56:38
date last changed
2017-11-09 10:53:11
@article{be554eb5-29d4-4f72-8fb0-dccb150a78ab,
  abstract     = {Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane (DiPiS) study. Mothers reported gestational infections when the child was 2 months old. Results Fever or gastroenteritis during pregnancy was reported by 2,848/19,756 mothers (14%); 339 in more than one trimester. Children whose mothers reported infections had increased risk of HrBW (p=0.0003), particularly in the absence of cord blood islet autoantibodies (interaction between HrBW, islet autoantibodies and infections, p=0.0005). The effect on HrBW by high-risk HLA-DQ2/8 was aggravated by infections in more than one trimester (odds ratio [OR]=5.24; p=0.003) (interaction; p=0.022). When infections were reported, cord blood islet autoantibodies decreased HrBW (OR=0.34; p=0.0002). Conclusions/intrepretation This study revealed that: (1) gestational fever, gastroenteritis, or both, increased the risk of HrBW; (2) cord blood islet autoantibodies decreased the risk of HrBW only in combination with infections; and (3) infections aggravated the association between HLA-DQ2/8 and HrBW. These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth.},
  author       = {Larsson, Helena and Lynch, Kristian and Lernmark, Barbro and Hansson, Gertie and Lernmark, Åke and Ivarsson, Sten and ,  and Carlsson, Annelie},
  issn         = {1432-0428},
  keyword      = {IA-2 autoantibodies,gestational,infections,HLA,GAD65 autoantibodies,gastroenteritis,birthweight,fever,type 1 diabetes,islet autoantibodies,autoantibodies,insulin},
  language     = {eng},
  number       = {6},
  pages        = {1161--1169},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.},
  url          = {http://dx.doi.org/10.1007/s00125-007-0648-6},
  volume       = {50},
  year         = {2007},
}