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First human transplantation of a nonacceptable donor lung after reconditioning ex vivo.

Steen, Stig LU ; Ingemansson, Richard LU ; Eriksson, Leif LU ; Pierre, Leif LU ; Algotsson, Lars LU ; Wierup, Per; Liao, Qiuming LU ; Eyjolfsson, Atli LU ; Gustafsson, Ronny LU and Sjöberg, Trygve LU (2007) In Annals of Thoracic Surgery 83(6). p.2191-2195
Abstract
Purpose. This article describes an ex vivo method to recondition and transplant rejected donor lungs. Description. A 19-year-old man was brain dead after a traffic accident. A roentgenogram showed bilateral lung contusion. He had ongoing intratracheal bleeding. After optimizing ventilator treatment and suctioning the airways, PaO2 was 9 kPa (67.5 mm Hg) on FiO(2) = 0.7. The lungs were rejected by all transplantation centers in the Nordic countries. We harvested the lungs for research. The right lung was severely injured. The left lung was edematous with bleeding spots in the lower lobe, and the mediobasal segment was atelectatic. The left lung was reconditioned ex vivo and kept in topical extracorporeal membrane oxygenation until it was... (More)
Purpose. This article describes an ex vivo method to recondition and transplant rejected donor lungs. Description. A 19-year-old man was brain dead after a traffic accident. A roentgenogram showed bilateral lung contusion. He had ongoing intratracheal bleeding. After optimizing ventilator treatment and suctioning the airways, PaO2 was 9 kPa (67.5 mm Hg) on FiO(2) = 0.7. The lungs were rejected by all transplantation centers in the Nordic countries. We harvested the lungs for research. The right lung was severely injured. The left lung was edematous with bleeding spots in the lower lobe, and the mediobasal segment was atelectatic. The left lung was reconditioned ex vivo and kept in topical extracorporeal membrane oxygenation until it was transplanted into a 70-year-old man with chronic obstructive pulmonary disease 17 hours later. Evaluation. The transplanted lung functioned very well, and the patient recovered uneventfully. At 3 months control, a computed tomographic thoracic scan and transbronchial biopsies showed a normal left lung, and the patient was in very good clinical condition, only to succumb to death from unrelated events 11 months after the transplantation. Conclusions. Rejected donor lungs may be successfully transplanted after being reconditioned ex vivo. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Thoracic Surgery
volume
83
issue
6
pages
2191 - 2195
publisher
Elsevier
external identifiers
  • wos:000246791200041
  • scopus:34249036433
ISSN
1552-6259
DOI
10.1016/j.athoracsur.2007.01.033
language
English
LU publication?
yes
id
e04a7344-0357-49b1-ad6e-9dfabb28264e (old id 168024)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17532422&dopt=Abstract
date added to LUP
2007-07-10 14:20:14
date last changed
2017-11-05 03:37:37
@article{e04a7344-0357-49b1-ad6e-9dfabb28264e,
  abstract     = {Purpose. This article describes an ex vivo method to recondition and transplant rejected donor lungs. Description. A 19-year-old man was brain dead after a traffic accident. A roentgenogram showed bilateral lung contusion. He had ongoing intratracheal bleeding. After optimizing ventilator treatment and suctioning the airways, PaO2 was 9 kPa (67.5 mm Hg) on FiO(2) = 0.7. The lungs were rejected by all transplantation centers in the Nordic countries. We harvested the lungs for research. The right lung was severely injured. The left lung was edematous with bleeding spots in the lower lobe, and the mediobasal segment was atelectatic. The left lung was reconditioned ex vivo and kept in topical extracorporeal membrane oxygenation until it was transplanted into a 70-year-old man with chronic obstructive pulmonary disease 17 hours later. Evaluation. The transplanted lung functioned very well, and the patient recovered uneventfully. At 3 months control, a computed tomographic thoracic scan and transbronchial biopsies showed a normal left lung, and the patient was in very good clinical condition, only to succumb to death from unrelated events 11 months after the transplantation. Conclusions. Rejected donor lungs may be successfully transplanted after being reconditioned ex vivo.},
  author       = {Steen, Stig and Ingemansson, Richard and Eriksson, Leif and Pierre, Leif and Algotsson, Lars and Wierup, Per and Liao, Qiuming and Eyjolfsson, Atli and Gustafsson, Ronny and Sjöberg, Trygve},
  issn         = {1552-6259},
  language     = {eng},
  number       = {6},
  pages        = {2191--2195},
  publisher    = {Elsevier},
  series       = {Annals of Thoracic Surgery},
  title        = {First human transplantation of a nonacceptable donor lung after reconditioning ex vivo.},
  url          = {http://dx.doi.org/10.1016/j.athoracsur.2007.01.033},
  volume       = {83},
  year         = {2007},
}