Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified t1-weighted steady-state cerebral blood volume approach.
Wirestam, Ronnie LU
; Knutsson, Linda
LU
; Risberg, Jarl
LU
; Börjesson, Siv
LU
; Larsson, Elna-Marie
LU
; Gustafson, Lars
LU
; Passant, Ulla
LU
and Ståhlberg, Freddy
LU
(2007)
In Acta Radiologica
48(5).
p.550-556
- Abstract
- Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each... (More)
- Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each individual. Average whole-brain CBF( DSC) was calculated, and the corrected MRI-based CBF estimate was given by CBF(ss)=KxCBF(DSC). Results: Average whole-brain SPECT CBF was 40.1 +/- 6.9 ml/min . 100 g, while the corresponding uncorrected DSC-MRI- based value was 69.2 +/- 13.8 ml/min . 100 g. After correction with the calibration factor, a CBF( ss) of 42.7 +/- 14.0 ml/min . 100 g was obtained. The linear fit to CBF( ss)-versus-CBF( SPECT) data was close to proportionality (R=0.52). Conclusion: Calibration by steady-state CBV reduced the population average CBF to a reasonable level, and a modest linear correlation with the reference Xe-133 SPECT technique was observed. Possible explanations for the limited accuracy are, for example, large-vessel partial-volume effects, low post-contrast signal enhancement in T1W images, and water-exchange effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/168119
- author
- Wirestam, Ronnie
LU
; Knutsson, Linda
LU
; Risberg, Jarl
LU
; Börjesson, Siv
LU
; Larsson, Elna-Marie
LU
; Gustafson, Lars
LU
; Passant, Ulla
LU
and Ståhlberg, Freddy
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hemodynamics/flow dynamics, brain/brain stem, MR diffusion/perfusion
- in
- Acta Radiologica
- volume
- 48
- issue
- 5
- pages
- 550 - 556
- publisher
- SAGE Publications
- external identifiers
-
- wos:000246786700013
- scopus:34249018581
- ISSN
- 1600-0455
- DOI
- 10.1080/02841850701280825
- project
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- language
- English
- LU publication?
- yes
- id
- 1cabc94b-a1a6-4c75-95a4-29b77334a15f (old id 168119)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17520432&dopt=Abstract
- date added to LUP
- 2016-04-01 16:21:16
- date last changed
- 2022-02-05 07:38:17
@article{1cabc94b-a1a6-4c75-95a4-29b77334a15f,
abstract = {{Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each individual. Average whole-brain CBF( DSC) was calculated, and the corrected MRI-based CBF estimate was given by CBF(ss)=KxCBF(DSC). Results: Average whole-brain SPECT CBF was 40.1 +/- 6.9 ml/min . 100 g, while the corresponding uncorrected DSC-MRI- based value was 69.2 +/- 13.8 ml/min . 100 g. After correction with the calibration factor, a CBF( ss) of 42.7 +/- 14.0 ml/min . 100 g was obtained. The linear fit to CBF( ss)-versus-CBF( SPECT) data was close to proportionality (R=0.52). Conclusion: Calibration by steady-state CBV reduced the population average CBF to a reasonable level, and a modest linear correlation with the reference Xe-133 SPECT technique was observed. Possible explanations for the limited accuracy are, for example, large-vessel partial-volume effects, low post-contrast signal enhancement in T1W images, and water-exchange effects.}},
author = {{Wirestam, Ronnie and Knutsson, Linda and Risberg, Jarl and Börjesson, Siv and Larsson, Elna-Marie and Gustafson, Lars and Passant, Ulla and Ståhlberg, Freddy}},
issn = {{1600-0455}},
keywords = {{hemodynamics/flow dynamics; brain/brain stem; MR diffusion/perfusion}},
language = {{eng}},
number = {{5}},
pages = {{550--556}},
publisher = {{SAGE Publications}},
series = {{Acta Radiologica}},
title = {{Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified t1-weighted steady-state cerebral blood volume approach.}},
url = {{http://dx.doi.org/10.1080/02841850701280825}},
doi = {{10.1080/02841850701280825}},
volume = {{48}},
year = {{2007}},
}