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Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified t1-weighted steady-state cerebral blood volume approach.

Wirestam, Ronnie LU ; Knutsson, Linda LU ; Risberg, Jarl LU ; Börjesson, Siv LU ; Larsson, Elna-Marie LU ; Gustafson, Lars LU ; Passant, Ulla LU and Ståhlberg, Freddy LU (2007) In Acta Radiologica 48(5). p.550-556
Abstract
Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each... (More)
Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each individual. Average whole-brain CBF( DSC) was calculated, and the corrected MRI-based CBF estimate was given by CBF(ss)=KxCBF(DSC). Results: Average whole-brain SPECT CBF was 40.1 +/- 6.9 ml/min . 100 g, while the corresponding uncorrected DSC-MRI- based value was 69.2 +/- 13.8 ml/min . 100 g. After correction with the calibration factor, a CBF( ss) of 42.7 +/- 14.0 ml/min . 100 g was obtained. The linear fit to CBF( ss)-versus-CBF( SPECT) data was close to proportionality (R=0.52). Conclusion: Calibration by steady-state CBV reduced the population average CBF to a reasonable level, and a modest linear correlation with the reference Xe-133 SPECT technique was observed. Possible explanations for the limited accuracy are, for example, large-vessel partial-volume effects, low post-contrast signal enhancement in T1W images, and water-exchange effects. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hemodynamics/flow dynamics, brain/brain stem, MR diffusion/perfusion
in
Acta Radiologica
volume
48
issue
5
pages
550 - 556
publisher
John Wiley & Sons
external identifiers
  • wos:000246786700013
  • scopus:34249018581
ISSN
1600-0455
DOI
10.1080/02841850701280825
language
English
LU publication?
yes
id
1cabc94b-a1a6-4c75-95a4-29b77334a15f (old id 168119)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17520432&dopt=Abstract
date added to LUP
2007-07-17 11:46:10
date last changed
2017-01-01 07:02:54
@article{1cabc94b-a1a6-4c75-95a4-29b77334a15f,
  abstract     = {Background: Attempts to retrieve absolute values of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) have typically resulted in overestimations. Purpose: To improve DSC-MRI CBF estimates by calibrating the DSC-MRI-based cerebral blood volume (CBV) with a corresponding T1-weighted (T1W) steady-state ( ss) CBV estimate. Material and Methods: 17 volunteers were investigated by DSC-MRI and Xe-133 SPECT. Steady-state CBV calculation, assuming no water exchange, was accomplished using signal values from blood and tissue, before and after contrast agent, obtained by T1W spin-echo imaging. Using steady-state and DSC-MRI CBV estimates, a calibration factor K=CBV(ss)/CBV(DSC) was obtained for each individual. Average whole-brain CBF( DSC) was calculated, and the corrected MRI-based CBF estimate was given by CBF(ss)=KxCBF(DSC). Results: Average whole-brain SPECT CBF was 40.1 +/- 6.9 ml/min . 100 g, while the corresponding uncorrected DSC-MRI- based value was 69.2 +/- 13.8 ml/min . 100 g. After correction with the calibration factor, a CBF( ss) of 42.7 +/- 14.0 ml/min . 100 g was obtained. The linear fit to CBF( ss)-versus-CBF( SPECT) data was close to proportionality (R=0.52). Conclusion: Calibration by steady-state CBV reduced the population average CBF to a reasonable level, and a modest linear correlation with the reference Xe-133 SPECT technique was observed. Possible explanations for the limited accuracy are, for example, large-vessel partial-volume effects, low post-contrast signal enhancement in T1W images, and water-exchange effects.},
  author       = {Wirestam, Ronnie and Knutsson, Linda and Risberg, Jarl and Börjesson, Siv and Larsson, Elna-Marie and Gustafson, Lars and Passant, Ulla and Ståhlberg, Freddy},
  issn         = {1600-0455},
  keyword      = {hemodynamics/flow dynamics,brain/brain stem,MR diffusion/perfusion},
  language     = {eng},
  number       = {5},
  pages        = {550--556},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Attempts to improve absolute quantification of cerebral blood flow in dynamic susceptibility contrast magnetic resonance imaging: a simplified t1-weighted steady-state cerebral blood volume approach.},
  url          = {http://dx.doi.org/10.1080/02841850701280825},
  volume       = {48},
  year         = {2007},
}