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Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes.

Nilsson, Charlotta; Ursing, Dag; Törn, Carina LU ; Åberg, Anders E LU and Landin-Olsson, Mona LU (2007) In Diabetes Care 30(8). p.1968-1971
Abstract
OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among... (More)
OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among the autoantibody-positive women, 50% had developed type I diabetes compared with none among the GDM control subjects (P = 0. 00 1), 2 1 % had impaired fasting glucose or impaired glucose tolerance compared with 12.5% among control subjects (P = 0.3), and none had developed type 2 diabetes compared with 12.5% among control subjects (P 0.1). CONCLUSIONS - Autoantibody screening in pregnant women with GDM and follow-up after delivery should be considered for early recognition of type I diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
30
issue
8
pages
1968 - 1971
publisher
American Diabetes Association
external identifiers
  • wos:000248570200005
  • scopus:34547656275
ISSN
1935-5548
DOI
10.2337/dc07-0157
language
English
LU publication?
yes
id
a627612a-8d39-48e9-a959-a19a407a2a39 (old id 168151)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17519433&dopt=Abstract
date added to LUP
2007-07-10 10:41:53
date last changed
2017-11-12 04:00:30
@article{a627612a-8d39-48e9-a959-a19a407a2a39,
  abstract     = {OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among the autoantibody-positive women, 50% had developed type I diabetes compared with none among the GDM control subjects (P = 0. 00 1), 2 1 % had impaired fasting glucose or impaired glucose tolerance compared with 12.5% among control subjects (P = 0.3), and none had developed type 2 diabetes compared with 12.5% among control subjects (P 0.1). CONCLUSIONS - Autoantibody screening in pregnant women with GDM and follow-up after delivery should be considered for early recognition of type I diabetes.},
  author       = {Nilsson, Charlotta and Ursing, Dag and Törn, Carina and Åberg, Anders E and Landin-Olsson, Mona},
  issn         = {1935-5548},
  language     = {eng},
  number       = {8},
  pages        = {1968--1971},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes.},
  url          = {http://dx.doi.org/10.2337/dc07-0157},
  volume       = {30},
  year         = {2007},
}