Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes.
(2007) In Diabetes Care 30(8). p.1968-1971- Abstract
- OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among... (More)
- OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among the autoantibody-positive women, 50% had developed type I diabetes compared with none among the GDM control subjects (P = 0. 00 1), 2 1 % had impaired fasting glucose or impaired glucose tolerance compared with 12.5% among control subjects (P = 0.3), and none had developed type 2 diabetes compared with 12.5% among control subjects (P 0.1). CONCLUSIONS - Autoantibody screening in pregnant women with GDM and follow-up after delivery should be considered for early recognition of type I diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/168151
- author
- Nilsson, Charlotta ; Ursing, Dag ; Törn, Carina LU ; Åberg, Anders E LU and Landin-Olsson, Mona LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 30
- issue
- 8
- pages
- 1968 - 1971
- publisher
- American Diabetes Association
- external identifiers
-
- wos:000248570200005
- scopus:34547656275
- ISSN
- 1935-5548
- DOI
- 10.2337/dc07-0157
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Diabetes and Endocrinology (013241530), Medicine (Lund) (013230025), Section I-II (013230011), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Division V (013230900), Diabetes and Celiac Unit (013241540)
- id
- a627612a-8d39-48e9-a959-a19a407a2a39 (old id 168151)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17519433&dopt=Abstract
- date added to LUP
- 2016-04-01 16:36:52
- date last changed
- 2024-11-09 03:13:56
@article{a627612a-8d39-48e9-a959-a19a407a2a39, abstract = {{OBJECTIVE - we sought to study the frequency of P-cell-specific autoantibody markers in women with gestational diabetes mellitus (GDM) and to follow these women to estimate the risk of later development of type I diabetes. RESEARCH DESIGN AND METHODS - Of 385 pregnant women with GDM during 1995-2005 in the district of Lund, 24 (6%) women were found positive for at least one of the following: islet cell antibody (ICA), GAD antibody (GADA), or tyrosine phosphatase antibody(IA-2A). The women were followed and autoantibodies reanalyzed. Those who had not developed diabetes did an oral glucose tolerance test. The frequencies of known risk factors; for GD were compared in women with GDM with and without pancreatic autoantibodies. RESULTS - Among the autoantibody-positive women, 50% had developed type I diabetes compared with none among the GDM control subjects (P = 0. 00 1), 2 1 % had impaired fasting glucose or impaired glucose tolerance compared with 12.5% among control subjects (P = 0.3), and none had developed type 2 diabetes compared with 12.5% among control subjects (P 0.1). CONCLUSIONS - Autoantibody screening in pregnant women with GDM and follow-up after delivery should be considered for early recognition of type I diabetes.}}, author = {{Nilsson, Charlotta and Ursing, Dag and Törn, Carina and Åberg, Anders E and Landin-Olsson, Mona}}, issn = {{1935-5548}}, language = {{eng}}, number = {{8}}, pages = {{1968--1971}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Presence of GAD-antibodies during gestational diabetes predicts type 1 diabetes.}}, url = {{http://dx.doi.org/10.2337/dc07-0157}}, doi = {{10.2337/dc07-0157}}, volume = {{30}}, year = {{2007}}, }