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Ductus venosus blood flow velocity waveform in diabetic pregnancies

Stuart, Andrea LU ; Amer-Wåhlin, Isis LU ; Gudmundsson, Saemundur LU ; Marsal, Karel LU ; Thuring, Ann LU and Källén, Karin LU (2010) In Ultrasound in Obstetrics & Gynecology 36(3). p.344-349
Abstract
Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing... (More)
Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing insulin-dependent (DM) or gestational diabetes when compared with normal reference values. Increased DV-PI values were still evident in both diabetic groups when neonates that were small-for-gestational age and neonates with pathological umbilical blood flow pattern were excluded from the analysis. In DM pregnancies a statistically significant correlation was found between DV-PI and maternal HbA1c. Conclusion Diabetic pregnancies exhibit increased DV-PI values when compared to a normal low-risk pregnant population, possibly indicating a fetal cardiac effect. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pulsatility index, large-for-gestational age, diabetes, ductus venosus
in
Ultrasound in Obstetrics & Gynecology
volume
36
issue
3
pages
344 - 349
publisher
John Wiley & Sons
external identifiers
  • wos:000282149900015
  • scopus:77956224833
ISSN
1469-0705
DOI
10.1002/uog.7573
language
English
LU publication?
yes
id
588707be-eaa3-4aae-8c7e-e85088809e7b (old id 1694023)
date added to LUP
2010-10-26 12:27:48
date last changed
2018-05-29 12:22:28
@article{588707be-eaa3-4aae-8c7e-e85088809e7b,
  abstract     = {Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing insulin-dependent (DM) or gestational diabetes when compared with normal reference values. Increased DV-PI values were still evident in both diabetic groups when neonates that were small-for-gestational age and neonates with pathological umbilical blood flow pattern were excluded from the analysis. In DM pregnancies a statistically significant correlation was found between DV-PI and maternal HbA1c. Conclusion Diabetic pregnancies exhibit increased DV-PI values when compared to a normal low-risk pregnant population, possibly indicating a fetal cardiac effect. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd.},
  author       = {Stuart, Andrea and Amer-Wåhlin, Isis and Gudmundsson, Saemundur and Marsal, Karel and Thuring, Ann and Källén, Karin},
  issn         = {1469-0705},
  keyword      = {pulsatility index,large-for-gestational age,diabetes,ductus venosus},
  language     = {eng},
  number       = {3},
  pages        = {344--349},
  publisher    = {John Wiley & Sons},
  series       = {Ultrasound in Obstetrics & Gynecology},
  title        = {Ductus venosus blood flow velocity waveform in diabetic pregnancies},
  url          = {http://dx.doi.org/10.1002/uog.7573},
  volume       = {36},
  year         = {2010},
}