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Antimicrobial resistance in colonizing group B Streptococci before the implementation of a Swedish intrapartum antibiotic prophylaxis program

Granlund, M.; Axemo, P.; Bremme, K.; Bryngelsson, A. -L.; Wallin, M. Carlsson; Ekstrom, C. -M.; Hakansson, S.; Jacobsson, B.; Källén, Karin LU and Spetz, E., et al. (2010) In European Journal of Clinical Microbiology & Infectious Diseases 29(10). p.1195-1201
Abstract
The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,000-mu g disks enabled a rapid and easy detection of these isolates. In all, 312/396 (79%) GBS were tetracycline-resistant and 95% of the examined isolates harbored the tetM gene. Among the 22 (5.5%) GBS resistant to erythromycin and/or clindamycin, the ermB gene was detected in nine isolates (41%) and erm(A/TR) in ten isolates (45%). A high level... (More)
The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,000-mu g disks enabled a rapid and easy detection of these isolates. In all, 312/396 (79%) GBS were tetracycline-resistant and 95% of the examined isolates harbored the tetM gene. Among the 22 (5.5%) GBS resistant to erythromycin and/or clindamycin, the ermB gene was detected in nine isolates (41%) and erm(A/TR) in ten isolates (45%). A high level of erythromycin and clindamycin resistance with minimum inhibitory concentrations (MICs) > 256 mg/L was found in four serotype V isolates that harbored ermB. The erythromycin/clindamycin resistance was distributed among all of the common serotypes Ia, Ib, II, III, IV, and V, but was not present in any of the 44 serotype III isolates associated to clonal complex 17. Screening for penicillin resistance with 1-mu g oxacillin disks showed a homogenous population with a mean inhibition zone of 20 mm. A change in the present oxacillin breakpoints for GBS is suggested. (Less)
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European Journal of Clinical Microbiology & Infectious Diseases
volume
29
issue
10
pages
1195 - 1201
publisher
Springer
external identifiers
  • wos:000281717900002
  • scopus:77957296593
ISSN
1435-4373
DOI
10.1007/s10096-010-0877-3
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English
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yes
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1b9c7d49-089c-42d6-9ea7-3b596edb3816 (old id 1697457)
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2010-10-25 09:59:22
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2018-05-29 12:31:27
@article{1b9c7d49-089c-42d6-9ea7-3b596edb3816,
  abstract     = {The prevalence of antibiotic resistance and their genetic determinants in colonizing group B streptococci (GBS) sampled in a Swedish nationwide survey was examined. In five GBS isolates (1.3%), kanamycin/amikacin resistance and the presence of the aphA-3 gene was identified. Three of these isolates carried the aad-6 gene and were streptomycin-resistant. Screening with kanamycin and streptomycin 1,000-mu g disks enabled a rapid and easy detection of these isolates. In all, 312/396 (79%) GBS were tetracycline-resistant and 95% of the examined isolates harbored the tetM gene. Among the 22 (5.5%) GBS resistant to erythromycin and/or clindamycin, the ermB gene was detected in nine isolates (41%) and erm(A/TR) in ten isolates (45%). A high level of erythromycin and clindamycin resistance with minimum inhibitory concentrations (MICs) > 256 mg/L was found in four serotype V isolates that harbored ermB. The erythromycin/clindamycin resistance was distributed among all of the common serotypes Ia, Ib, II, III, IV, and V, but was not present in any of the 44 serotype III isolates associated to clonal complex 17. Screening for penicillin resistance with 1-mu g oxacillin disks showed a homogenous population with a mean inhibition zone of 20 mm. A change in the present oxacillin breakpoints for GBS is suggested.},
  author       = {Granlund, M. and Axemo, P. and Bremme, K. and Bryngelsson, A. -L. and Wallin, M. Carlsson and Ekstrom, C. -M. and Hakansson, S. and Jacobsson, B. and Källén, Karin and Spetz, E. and Tessin, I.},
  issn         = {1435-4373},
  language     = {eng},
  number       = {10},
  pages        = {1195--1201},
  publisher    = {Springer},
  series       = {European Journal of Clinical Microbiology & Infectious Diseases},
  title        = {Antimicrobial resistance in colonizing group B Streptococci before the implementation of a Swedish intrapartum antibiotic prophylaxis program},
  url          = {http://dx.doi.org/10.1007/s10096-010-0877-3},
  volume       = {29},
  year         = {2010},
}