Increased alveolar nitric oxide in early systemic sclerosis.
(2010) In Clinical and Experimental Rheumatology 28(5 Suppl 62). p.5-9- Abstract
- OBJECTIVES: Assessment of inflammatory activity in interstitial lung disease of systemic sclerosis (SSc) is difficult. Nitric oxide (NO) has gained attention in the pathogenesis of SSc. The aim of the study was to investigate alveolar NO concentration (CA(NO)) in SSc patients with short disease duration and to relate CA(NO) to radiologic findings. METHODS: In a prospective study, 34 consecutive patients with disease duration of less than 2 years from onset of first non-Raynaud symptom and 26 healthy controls were enrolled. Exhaled NO was measured and CA(NO) was calculated. CA(NO) levels were related to the radiologic extent of pulmonary fibrosis measured as the extent of traction bronchiectasis within areas of ground glass opacities and... (More)
- OBJECTIVES: Assessment of inflammatory activity in interstitial lung disease of systemic sclerosis (SSc) is difficult. Nitric oxide (NO) has gained attention in the pathogenesis of SSc. The aim of the study was to investigate alveolar NO concentration (CA(NO)) in SSc patients with short disease duration and to relate CA(NO) to radiologic findings. METHODS: In a prospective study, 34 consecutive patients with disease duration of less than 2 years from onset of first non-Raynaud symptom and 26 healthy controls were enrolled. Exhaled NO was measured and CA(NO) was calculated. CA(NO) levels were related to the radiologic extent of pulmonary fibrosis measured as the extent of traction bronchiectasis within areas of ground glass opacities and reticulations. RESULTS: CA(NO) levels were increased in patients with early SSc compared to healthy controls (3.52 (2.94-4.09) versus 2.08 (1.6-2.6); p<0.001). Both SSc patients with SSc-ILD (3.56 (3.04-4.73), p<0.001) and SSc patients without SSc-ILD (2.98 (2.68-3.98), p<0.01) had higher CA(NO) levels compared with healthy controls (2.08 (1.6-2.6)). CA(NO) levels did not differ between SSc patients without SSc-ILD and SSc patients with SSC-ILD. CA(NO) levels did not correlate to the extent of pulmonary fibrosis but were associated with the extent of ground glass opacities (rs=0.37, p<0.05) and reticulations (rs=0.37, p<0.05) on HRCT. CA(NO) levels were not correlated to lung function tests. CONCLUSIONS: In patients with early SSc, alveolar NO is increased and may precede radiological changes of SSc-ILD. CA(NO) may therefore be a marker of early lung involvement. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731792
- author
- Wuttge, Dirk LU ; Bozovic, Gracijela LU ; Hesselstrand, Roger LU ; Aronsson, David LU ; Bjermer, Leif LU ; Scheja, Agneta LU and Tufvesson, Ellen LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical and Experimental Rheumatology
- volume
- 28
- issue
- 5 Suppl 62
- pages
- 5 - 9
- publisher
- Pacini
- external identifiers
-
- wos:000284028600002
- pmid:21050538
- scopus:78650567530
- ISSN
- 1593-098X
- language
- English
- LU publication?
- yes
- id
- dba97302-c104-42b0-ba84-a19507bfd67b (old id 1731792)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21050538?dopt=Abstract
- date added to LUP
- 2016-04-04 07:52:54
- date last changed
- 2022-01-29 02:43:36
@article{dba97302-c104-42b0-ba84-a19507bfd67b, abstract = {{OBJECTIVES: Assessment of inflammatory activity in interstitial lung disease of systemic sclerosis (SSc) is difficult. Nitric oxide (NO) has gained attention in the pathogenesis of SSc. The aim of the study was to investigate alveolar NO concentration (CA(NO)) in SSc patients with short disease duration and to relate CA(NO) to radiologic findings. METHODS: In a prospective study, 34 consecutive patients with disease duration of less than 2 years from onset of first non-Raynaud symptom and 26 healthy controls were enrolled. Exhaled NO was measured and CA(NO) was calculated. CA(NO) levels were related to the radiologic extent of pulmonary fibrosis measured as the extent of traction bronchiectasis within areas of ground glass opacities and reticulations. RESULTS: CA(NO) levels were increased in patients with early SSc compared to healthy controls (3.52 (2.94-4.09) versus 2.08 (1.6-2.6); p<0.001). Both SSc patients with SSc-ILD (3.56 (3.04-4.73), p<0.001) and SSc patients without SSc-ILD (2.98 (2.68-3.98), p<0.01) had higher CA(NO) levels compared with healthy controls (2.08 (1.6-2.6)). CA(NO) levels did not differ between SSc patients without SSc-ILD and SSc patients with SSC-ILD. CA(NO) levels did not correlate to the extent of pulmonary fibrosis but were associated with the extent of ground glass opacities (rs=0.37, p<0.05) and reticulations (rs=0.37, p<0.05) on HRCT. CA(NO) levels were not correlated to lung function tests. CONCLUSIONS: In patients with early SSc, alveolar NO is increased and may precede radiological changes of SSc-ILD. CA(NO) may therefore be a marker of early lung involvement.}}, author = {{Wuttge, Dirk and Bozovic, Gracijela and Hesselstrand, Roger and Aronsson, David and Bjermer, Leif and Scheja, Agneta and Tufvesson, Ellen}}, issn = {{1593-098X}}, language = {{eng}}, number = {{5 Suppl 62}}, pages = {{5--9}}, publisher = {{Pacini}}, series = {{Clinical and Experimental Rheumatology}}, title = {{Increased alveolar nitric oxide in early systemic sclerosis.}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/21050538?dopt=Abstract}}, volume = {{28}}, year = {{2010}}, }