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Enterolactone and breast cancer: methodological issues may contribute to conflicting results in observational studies.

Sonestedt, Emily LU and Wirfält, Elisabet LU (2010) In Nutrition Research 30(10). p.667-677
Abstract
Lignans found in plant foods are converted by the intestinal microflora to enterolignans. The structure of enterolignans is similar to that of estrogens, which has inspired researchers to examine a potential protective association in relation to health outcomes. Numerous epidemiological studies have measured concentration of enterolignans, mainly enterolactone, in blood or urine as a biomarker of lignan exposure and studied its relation to breast cancer risk. Case-control studies have shown decreased breast cancer risk associated with high circulating enterolactone concentrations, but results demonstrated by prospective cohort studies are less clear. The purpose of this review is to discuss factors that may contribute to these... (More)
Lignans found in plant foods are converted by the intestinal microflora to enterolignans. The structure of enterolignans is similar to that of estrogens, which has inspired researchers to examine a potential protective association in relation to health outcomes. Numerous epidemiological studies have measured concentration of enterolignans, mainly enterolactone, in blood or urine as a biomarker of lignan exposure and studied its relation to breast cancer risk. Case-control studies have shown decreased breast cancer risk associated with high circulating enterolactone concentrations, but results demonstrated by prospective cohort studies are less clear. The purpose of this review is to discuss factors that may contribute to these contradictory findings obtained in epidemiological studies, including age distribution, enterolactone measurement error, heterogeneity of breast cancer subtypes, and genetic factors. Different sources of enterolactone precursors may also contribute to inconclusive results. In conclusion, to get robust evidence of the health effects of lignans and enterolactone, more effort has to be put on methodological problems, including reducing measurement errors in enterolactone estimation, and to identify factors that modify the effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrition Research
volume
30
issue
10
pages
667 - 677
publisher
Elsevier
external identifiers
  • wos:000284456300001
  • pmid:21056282
  • scopus:78149274896
ISSN
0271-5317
DOI
10.1016/j.nutres.2010.09.010
language
English
LU publication?
yes
id
acb9798d-87b1-4b20-b87b-9939802b30b5 (old id 1732222)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21056282?dopt=Abstract
date added to LUP
2010-12-01 10:49:33
date last changed
2018-05-29 11:01:45
@article{acb9798d-87b1-4b20-b87b-9939802b30b5,
  abstract     = {Lignans found in plant foods are converted by the intestinal microflora to enterolignans. The structure of enterolignans is similar to that of estrogens, which has inspired researchers to examine a potential protective association in relation to health outcomes. Numerous epidemiological studies have measured concentration of enterolignans, mainly enterolactone, in blood or urine as a biomarker of lignan exposure and studied its relation to breast cancer risk. Case-control studies have shown decreased breast cancer risk associated with high circulating enterolactone concentrations, but results demonstrated by prospective cohort studies are less clear. The purpose of this review is to discuss factors that may contribute to these contradictory findings obtained in epidemiological studies, including age distribution, enterolactone measurement error, heterogeneity of breast cancer subtypes, and genetic factors. Different sources of enterolactone precursors may also contribute to inconclusive results. In conclusion, to get robust evidence of the health effects of lignans and enterolactone, more effort has to be put on methodological problems, including reducing measurement errors in enterolactone estimation, and to identify factors that modify the effect.},
  author       = {Sonestedt, Emily and Wirfält, Elisabet},
  issn         = {0271-5317},
  language     = {eng},
  number       = {10},
  pages        = {667--677},
  publisher    = {Elsevier},
  series       = {Nutrition Research},
  title        = {Enterolactone and breast cancer: methodological issues may contribute to conflicting results in observational studies.},
  url          = {http://dx.doi.org/10.1016/j.nutres.2010.09.010},
  volume       = {30},
  year         = {2010},
}