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Survival in cancer patients with previous hospitalization for sarcoidosis: a Swedish population-based cohort study during 1964-2006.

Shu, Xiaochen LU ; Ji, Jianguang LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2011) In Annals of Oncology 22. p.1427-1434
Abstract
BACKGROUND: Sarcoidosis has been reported to be associated with an increased risk of cancer; however, little information is available about the prognosis for sarcoidosis patients diagnosed with cancer. PATIENTS AND METHODS: A population-based cohort of sarcoidosis patients was identified from Swedish registers. Cause-specific and overall hazard ratios (HRs) were estimated by using Cox regression model to show the probability of death in the study group compared with the control population. RESULTS: A total of 1167 sarcoidosis patients were identified with subsequent cancer compared with 1 023 725 cancer patients without sarcoidosis from 1964 to 2006, showing a significant survival disparity [overall HR 1.21, 95% confidence interval (CI)... (More)
BACKGROUND: Sarcoidosis has been reported to be associated with an increased risk of cancer; however, little information is available about the prognosis for sarcoidosis patients diagnosed with cancer. PATIENTS AND METHODS: A population-based cohort of sarcoidosis patients was identified from Swedish registers. Cause-specific and overall hazard ratios (HRs) were estimated by using Cox regression model to show the probability of death in the study group compared with the control population. RESULTS: A total of 1167 sarcoidosis patients were identified with subsequent cancer compared with 1 023 725 cancer patients without sarcoidosis from 1964 to 2006, showing a significant survival disparity [overall HR 1.21, 95% confidence interval (CI) 1.13-1.30 and cause-specific HR 1.16, 95% CI 1.08-1.27]. Site-specific analyses revealed that an overall mortality excess in sarcoidosis patients was observed for six cancers in comparison with a cancer-specific mortality excess for four cancers. Notably, stratified analyses showed that the prognosis was worse for cancer patients diagnosed below age 65 years. Cancer sites with significant mortality excess after sarcoidosis were mutually exclusive for men and women. CONCLUSIONS: A previously diagnosed sarcoidosis worsens the prognosis of cancer, preferentially for those diagnosed at a relatively younger age. The underlying mechanisms and more prognostic factors warrant further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Oncology
volume
22
pages
1427 - 1434
publisher
Oxford University Press
external identifiers
  • wos:000291060800025
  • pmid:21186236
  • scopus:79957838430
ISSN
1569-8041
DOI
10.1093/annonc/mdq614
language
English
LU publication?
yes
id
1848a0cd-dfdf-4c4a-b8b0-93e3e62d3f7d (old id 1755788)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21186236?dopt=Abstract
date added to LUP
2011-01-03 11:10:08
date last changed
2017-01-01 07:51:26
@article{1848a0cd-dfdf-4c4a-b8b0-93e3e62d3f7d,
  abstract     = {BACKGROUND: Sarcoidosis has been reported to be associated with an increased risk of cancer; however, little information is available about the prognosis for sarcoidosis patients diagnosed with cancer. PATIENTS AND METHODS: A population-based cohort of sarcoidosis patients was identified from Swedish registers. Cause-specific and overall hazard ratios (HRs) were estimated by using Cox regression model to show the probability of death in the study group compared with the control population. RESULTS: A total of 1167 sarcoidosis patients were identified with subsequent cancer compared with 1 023 725 cancer patients without sarcoidosis from 1964 to 2006, showing a significant survival disparity [overall HR 1.21, 95% confidence interval (CI) 1.13-1.30 and cause-specific HR 1.16, 95% CI 1.08-1.27]. Site-specific analyses revealed that an overall mortality excess in sarcoidosis patients was observed for six cancers in comparison with a cancer-specific mortality excess for four cancers. Notably, stratified analyses showed that the prognosis was worse for cancer patients diagnosed below age 65 years. Cancer sites with significant mortality excess after sarcoidosis were mutually exclusive for men and women. CONCLUSIONS: A previously diagnosed sarcoidosis worsens the prognosis of cancer, preferentially for those diagnosed at a relatively younger age. The underlying mechanisms and more prognostic factors warrant further investigation.},
  author       = {Shu, Xiaochen and Ji, Jianguang and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {1569-8041},
  language     = {eng},
  pages        = {1427--1434},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Survival in cancer patients with previous hospitalization for sarcoidosis: a Swedish population-based cohort study during 1964-2006.},
  url          = {http://dx.doi.org/10.1093/annonc/mdq614},
  volume       = {22},
  year         = {2011},
}