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Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis.

Bremander, Ann LU ; Petersson, Ingemar LU ; Bergman, Stefan LU and Englund, Martin LU (2011) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 63(4). p.550-556
Abstract
OBJECTIVE:: To study the rate of common comorbidities and cardiovascular disease in ankylosing spondylitis (AS) patients compared with the general population seeking health care. METHODS:: This cohort study included 935 subjects (67% men) age ≥20 years, diagnosed with AS and the adult background population in southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic codes for a select number of comorbidities commonly associated with AS and cardiovascular disease and risk factors. We obtained standardized morbidity-rate ratios (SMRs) by dividing the observed morbidity rate in AS patients by the expected rate based on the corresponding rate of the disease in the general population of the county seeking health... (More)
OBJECTIVE:: To study the rate of common comorbidities and cardiovascular disease in ankylosing spondylitis (AS) patients compared with the general population seeking health care. METHODS:: This cohort study included 935 subjects (67% men) age ≥20 years, diagnosed with AS and the adult background population in southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic codes for a select number of comorbidities commonly associated with AS and cardiovascular disease and risk factors. We obtained standardized morbidity-rate ratios (SMRs) by dividing the observed morbidity rate in AS patients by the expected rate based on the corresponding rate of the disease in the general population of the county seeking health care. RESULTS:: The highest SMRs were found for uveitis 34.35 (95% confidence interval [95% CI] 28.55, 40.98) and inflammatory bowel disease 9.28 (95% CI 7.07, 11.97). Also, we found increased SMRs for ischemic heart diseases 2.20 (95% CI 1.77, 2.70), hypertension 1.98 (95% CI 1.72, 2.28), and diabetes mellitus 1.41 (95% CI 1.10, 1.78). Further, the SMRs for psoriasis, osteoporosis, and atrioventricular blocks were also statistically significantly elevated. CONCLUSION:: Inflammatory diseases affecting the eye and the digestive system were the most notable comorbidities in AS patients, but the rate for cardiovascular disease was also high. Comprehensive longitudinal population-based register data is a promising tool to evaluate the excess consultation rate and total burden of rheumatic disease on patient and society. (Less)
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author
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Contribution to journal
publication status
published
subject
in
Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
63
issue
4
pages
550 - 556
publisher
John Wiley & Sons
external identifiers
  • wos:000289422700010
  • pmid:21120964
  • scopus:79957505703
ISSN
2151-4658
DOI
10.1002/acr.20408
language
English
LU publication?
yes
id
64dd33d5-9fd8-4f81-adfc-b0b74c2f37ad (old id 1756880)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21120964?dopt=Abstract
date added to LUP
2011-01-03 11:47:48
date last changed
2017-11-12 03:03:01
@article{64dd33d5-9fd8-4f81-adfc-b0b74c2f37ad,
  abstract     = {OBJECTIVE:: To study the rate of common comorbidities and cardiovascular disease in ankylosing spondylitis (AS) patients compared with the general population seeking health care. METHODS:: This cohort study included 935 subjects (67% men) age ≥20 years, diagnosed with AS and the adult background population in southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic codes for a select number of comorbidities commonly associated with AS and cardiovascular disease and risk factors. We obtained standardized morbidity-rate ratios (SMRs) by dividing the observed morbidity rate in AS patients by the expected rate based on the corresponding rate of the disease in the general population of the county seeking health care. RESULTS:: The highest SMRs were found for uveitis 34.35 (95% confidence interval [95% CI] 28.55, 40.98) and inflammatory bowel disease 9.28 (95% CI 7.07, 11.97). Also, we found increased SMRs for ischemic heart diseases 2.20 (95% CI 1.77, 2.70), hypertension 1.98 (95% CI 1.72, 2.28), and diabetes mellitus 1.41 (95% CI 1.10, 1.78). Further, the SMRs for psoriasis, osteoporosis, and atrioventricular blocks were also statistically significantly elevated. CONCLUSION:: Inflammatory diseases affecting the eye and the digestive system were the most notable comorbidities in AS patients, but the rate for cardiovascular disease was also high. Comprehensive longitudinal population-based register data is a promising tool to evaluate the excess consultation rate and total burden of rheumatic disease on patient and society.},
  author       = {Bremander, Ann and Petersson, Ingemar and Bergman, Stefan and Englund, Martin},
  issn         = {2151-4658},
  language     = {eng},
  number       = {4},
  pages        = {550--556},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis.},
  url          = {http://dx.doi.org/10.1002/acr.20408},
  volume       = {63},
  year         = {2011},
}