Advanced

Reduced cerebral perfusion in elderly men with silent myocardial ischaemia and nocturnal blood pressure dipping

Furuäng, Linda LU ; Siennicki-Lantz, Arkadiusz LU and Elmståhl, Sölve LU (2011) In Atherosclerosis 214(1). p.231-236
Abstract
OBJECTIVE: Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse. The aim of our study is to examine the association between cerebral blood flow (CBF), silent ST segment depression (STDE) on ambulatory ECG (LTER) and nocturnal blood pressure variations in elderly men. METHODS: In a cross-sectional cohort study "Men born in 1914", eighty 83-year-old men were examined by CBF, LTER and ambulatory blood pressure monitoring (ABPM). The presence and the degree of STDE were analyzed in relation to regional CBF in nocturnal blood pressure dippers/non-dippers. RESULTS: Fourty-five (56%) study subjects had STDE, 25 at both day and night and 20 only daytime. Subjects with STDE expressed lower... (More)
OBJECTIVE: Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse. The aim of our study is to examine the association between cerebral blood flow (CBF), silent ST segment depression (STDE) on ambulatory ECG (LTER) and nocturnal blood pressure variations in elderly men. METHODS: In a cross-sectional cohort study "Men born in 1914", eighty 83-year-old men were examined by CBF, LTER and ambulatory blood pressure monitoring (ABPM). The presence and the degree of STDE were analyzed in relation to regional CBF in nocturnal blood pressure dippers/non-dippers. RESULTS: Fourty-five (56%) study subjects had STDE, 25 at both day and night and 20 only daytime. Subjects with STDE expressed lower CBF in left frontal, temporal, inferior parietal regions and bilateral superior parietal regions compared to men without STDE. Low regional CBF was most frequent in subjects with daytime STDE. Subjects with nocturnal diastolic blood pressure dip and STDE (22 subjects; 35%) had lower mean CBF in the parietal lobe and also correlation between STDE and CBF (r=0.31-0.44, p=0.056-0.006) compared to non-dippers with STDE. The lowest CBF in nocturnal dippers was observed in subjects with maximal STDE daytime. CONCLUSION: Silent myocardial ischemia may contribute to cerebrovascular disease in non-demented elderly men. Cerebral perfusion seems to be most vulnerable to myocardial ischemia in elderly with nocturnal blood pressure dipping. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
214
issue
1
pages
231 - 236
publisher
Elsevier
external identifiers
  • wos:000285994600039
  • scopus:78650826463
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2010.10.043
language
English
LU publication?
yes
id
a76a4713-bc64-41ea-96f1-994ed65c3c1b (old id 1761883)
date added to LUP
2011-02-17 10:21:33
date last changed
2017-05-21 03:13:53
@article{a76a4713-bc64-41ea-96f1-994ed65c3c1b,
  abstract     = {OBJECTIVE: Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse. The aim of our study is to examine the association between cerebral blood flow (CBF), silent ST segment depression (STDE) on ambulatory ECG (LTER) and nocturnal blood pressure variations in elderly men. METHODS: In a cross-sectional cohort study "Men born in 1914", eighty 83-year-old men were examined by CBF, LTER and ambulatory blood pressure monitoring (ABPM). The presence and the degree of STDE were analyzed in relation to regional CBF in nocturnal blood pressure dippers/non-dippers. RESULTS: Fourty-five (56%) study subjects had STDE, 25 at both day and night and 20 only daytime. Subjects with STDE expressed lower CBF in left frontal, temporal, inferior parietal regions and bilateral superior parietal regions compared to men without STDE. Low regional CBF was most frequent in subjects with daytime STDE. Subjects with nocturnal diastolic blood pressure dip and STDE (22 subjects; 35%) had lower mean CBF in the parietal lobe and also correlation between STDE and CBF (r=0.31-0.44, p=0.056-0.006) compared to non-dippers with STDE. The lowest CBF in nocturnal dippers was observed in subjects with maximal STDE daytime. CONCLUSION: Silent myocardial ischemia may contribute to cerebrovascular disease in non-demented elderly men. Cerebral perfusion seems to be most vulnerable to myocardial ischemia in elderly with nocturnal blood pressure dipping.},
  author       = {Furuäng, Linda and Siennicki-Lantz, Arkadiusz and Elmståhl, Sölve},
  issn         = {1879-1484},
  language     = {eng},
  number       = {1},
  pages        = {231--236},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Reduced cerebral perfusion in elderly men with silent myocardial ischaemia and nocturnal blood pressure dipping},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2010.10.043},
  volume       = {214},
  year         = {2011},
}