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Gene therapy of focal-onset epilepsy by adeno-associated virus vector-mediated overexpression of neuropeptide Y

Noe, Francesco M.; Toft Sörensen, Andreas LU ; Kokaia, Merab LU and Vezzani, Annamaria (2010) In Epilepsia 51. p.96-96
Abstract
P>Adeno-associated virus (AAV)-mediated neuropeptide Y (NPY) overexpression in areas of seizure onset or generalization may be effective for the treatment of pharmacoresistant seizures in focal onset epilepsy. NPY overexpression mediates anticonvulsant activity in various seizures models and antiepileptogenic effects in kindling. Side effects are limited thus suggesting that this therapeutic approach could be effective and relatively safe. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at... (More)
P>Adeno-associated virus (AAV)-mediated neuropeptide Y (NPY) overexpression in areas of seizure onset or generalization may be effective for the treatment of pharmacoresistant seizures in focal onset epilepsy. NPY overexpression mediates anticonvulsant activity in various seizures models and antiepileptogenic effects in kindling. Side effects are limited thus suggesting that this therapeutic approach could be effective and relatively safe. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pharmacoresistant seizures, Kindling, Gene overexpression, Kainic acid, Viral vector
in
Epilepsia
volume
51
pages
96 - 96
publisher
Wiley-Blackwell
external identifiers
  • wos:000285388600091
  • scopus:78650348086
ISSN
0013-9580
DOI
10.1111/j.1528-1167.2010.02882.x
language
English
LU publication?
yes
id
4602061c-35a0-4adb-8771-4a90e2ba789d (old id 1772303)
date added to LUP
2011-02-02 15:02:49
date last changed
2018-05-29 09:29:29
@article{4602061c-35a0-4adb-8771-4a90e2ba789d,
  abstract     = {P>Adeno-associated virus (AAV)-mediated neuropeptide Y (NPY) overexpression in areas of seizure onset or generalization may be effective for the treatment of pharmacoresistant seizures in focal onset epilepsy. NPY overexpression mediates anticonvulsant activity in various seizures models and antiepileptogenic effects in kindling. Side effects are limited thus suggesting that this therapeutic approach could be effective and relatively safe. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).},
  author       = {Noe, Francesco M. and Toft Sörensen, Andreas and Kokaia, Merab and Vezzani, Annamaria},
  issn         = {0013-9580},
  keyword      = {Pharmacoresistant seizures,Kindling,Gene overexpression,Kainic acid,Viral vector},
  language     = {eng},
  pages        = {96--96},
  publisher    = {Wiley-Blackwell},
  series       = {Epilepsia},
  title        = {Gene therapy of focal-onset epilepsy by adeno-associated virus vector-mediated overexpression of neuropeptide Y},
  url          = {http://dx.doi.org/10.1111/j.1528-1167.2010.02882.x},
  volume       = {51},
  year         = {2010},
}