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Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition

Rohrmann, Sabine; Linseisen, Jakob; Jakobsen, Marianne Uhre; Overvad, Kim; Raaschou-Nielsen, Ole; Tjonneland, Anne; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Becker, Nikolaus and Bergmann, Manuela, et al. (2011) In International Journal of Cancer 128(3). p.623-634
Abstract
The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an... (More)
The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [ relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies. (Less)
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publication status
published
subject
keywords
dairy consumption, lymhomas, meat consumption, cohort study
in
International Journal of Cancer
volume
128
issue
3
pages
623 - 634
publisher
John Wiley & Sons
external identifiers
  • wos:000285264000013
  • scopus:78649805294
ISSN
0020-7136
DOI
10.1002/ijc.25387
language
English
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yes
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1b0b6461-92a3-4e89-967a-ee9529af36d3 (old id 1773940)
date added to LUP
2011-02-01 10:14:00
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2017-09-17 03:19:01
@article{1b0b6461-92a3-4e89-967a-ee9529af36d3,
  abstract     = {The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [ relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Jakobsen, Marianne Uhre and Overvad, Kim and Raaschou-Nielsen, Ole and Tjonneland, Anne and Boutron-Ruault, Marie Christine and Kaaks, Rudolf and Becker, Nikolaus and Bergmann, Manuela and Boeing, Heiner and Khaw, Kay-Tee and Wareham, Nicholas J. and Key, Timothy J. and Travis, Ruth and Benetou, Vassiliki and Naska, Androniki and Trichopoulou, Antonia and Pala, Valeria and Tumino, Rosario and Masala, Giovanna and Mattiello, Amalia and Brustad, Magritt and Lund, Eiliv and Skeie, Guri and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. and Vermeulen, Roel C. H. and Jakszyn, Paula and Dorronsoro, Miren and Barricarte, Aurelio and Tormo, Maria-Jose and Molina, Esther and Argueelles, Marcial and Melin, Beatrice and Ericson, Ulrika and Manjer, Jonas and Rinaldi, Sabina and Slimani, Nadia and Boffetta, Paolo and Vergnaud, Anne-Claire and Khan, Aneire and Norat, Teresa and Vineis, Paolo},
  issn         = {0020-7136},
  keyword      = {dairy consumption,lymhomas,meat consumption,cohort study},
  language     = {eng},
  number       = {3},
  pages        = {623--634},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.25387},
  volume       = {128},
  year         = {2011},
}