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The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells.

Wang, Feng; Chen, Jibing; Shao, Wei; Kang, Xiangpeng; Xu, Shuo; Xia, Junjie; Dai, Helong; Peng, Yuanzheng; Thorlacius, Henrik LU and Xing, Jinchun, et al. (2011) In Scandinavian Journal of Immunology 73. p.190-197
Abstract
Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of... (More)
Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens, and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells. (Less)
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Scandinavian Journal of Immunology
volume
73
pages
190 - 197
publisher
Wiley-Blackwell
external identifiers
  • wos:000287092100002
  • pmid:21204892
  • scopus:79551679378
ISSN
1365-3083
DOI
10.1111/j.1365-3083.2010.02493.x
language
English
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yes
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947ec241-eaf6-4032-bd36-9b75bd6d4629 (old id 1777833)
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http://www.ncbi.nlm.nih.gov/pubmed/21204892?dopt=Abstract
date added to LUP
2011-02-01 10:46:02
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2017-01-01 07:45:18
@article{947ec241-eaf6-4032-bd36-9b75bd6d4629,
  abstract     = {Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens, and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells.},
  author       = {Wang, Feng and Chen, Jibing and Shao, Wei and Kang, Xiangpeng and Xu, Shuo and Xia, Junjie and Dai, Helong and Peng, Yuanzheng and Thorlacius, Henrik and Xing, Jinchun and Qi, Zhongquan},
  issn         = {1365-3083},
  language     = {eng},
  pages        = {190--197},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Immunology},
  title        = {The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells.},
  url          = {http://dx.doi.org/10.1111/j.1365-3083.2010.02493.x},
  volume       = {73},
  year         = {2011},
}