Current challenges and coming opportunities in nanoparticle risk assessment
(2020) In Frontiers of Nanoscience 16. p.353-371- Abstract
This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the... (More)
This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.
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- author
- Bondarenko, Olesja M. ; Krais, Annette M. LU and Farrera, Consol
- organization
- publishing date
- 2020-04-24
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Nanosafety, Nanotechnology, Nanotoxicology
- host publication
- Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications - Synthesis, Characterization and Potential Applications
- series title
- Frontiers of Nanoscience
- editor
- Parak, Wolfgang J. and Feliu, Neus
- volume
- 16
- pages
- 19 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85083671333
- ISSN
- 1876-276X
- 1876-2778
- ISBN
- 978-0-08-102828-5
- DOI
- 10.1016/B978-0-08-102828-5.00013-9
- language
- English
- LU publication?
- yes
- id
- 178ff4e2-0a7f-44c0-b230-87237c703271
- date added to LUP
- 2020-05-28 16:14:04
- date last changed
- 2024-09-04 23:53:19
@inbook{178ff4e2-0a7f-44c0-b230-87237c703271, abstract = {{<p>This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.</p>}}, author = {{Bondarenko, Olesja M. and Krais, Annette M. and Farrera, Consol}}, booktitle = {{Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications}}, editor = {{Parak, Wolfgang J. and Feliu, Neus}}, isbn = {{978-0-08-102828-5}}, issn = {{1876-276X}}, keywords = {{Nanosafety; Nanotechnology; Nanotoxicology}}, language = {{eng}}, month = {{04}}, pages = {{353--371}}, publisher = {{Elsevier}}, series = {{Frontiers of Nanoscience}}, title = {{Current challenges and coming opportunities in nanoparticle risk assessment}}, url = {{http://dx.doi.org/10.1016/B978-0-08-102828-5.00013-9}}, doi = {{10.1016/B978-0-08-102828-5.00013-9}}, volume = {{16}}, year = {{2020}}, }