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Current challenges and coming opportunities in nanoparticle risk assessment

Bondarenko, Olesja M. ; Krais, Annette M. LU and Farrera, Consol (2020) In Frontiers of Nanoscience 16. p.353-371
Abstract

This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the... (More)

This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Nanosafety, Nanotechnology, Nanotoxicology
host publication
Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications - Synthesis, Characterization and Potential Applications
series title
Frontiers of Nanoscience
editor
Parak, Wolfgang J. ; Feliu, Neus ; and
volume
16
pages
19 pages
publisher
Elsevier Ltd
external identifiers
  • scopus:85083671333
ISSN
1876-276X
1876-2778
ISBN
978-0-08-102828-5
DOI
10.1016/B978-0-08-102828-5.00013-9
language
English
LU publication?
yes
id
178ff4e2-0a7f-44c0-b230-87237c703271
date added to LUP
2020-05-28 16:14:04
date last changed
2020-05-29 01:58:35
@inbook{178ff4e2-0a7f-44c0-b230-87237c703271,
  abstract     = {<p>This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.</p>},
  author       = {Bondarenko, Olesja M. and Krais, Annette M. and Farrera, Consol},
  booktitle    = {Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications},
  editor       = {Parak, Wolfgang J.  and Feliu, Neus },
  isbn         = {978-0-08-102828-5},
  issn         = {1876-276X},
  language     = {eng},
  month        = {04},
  pages        = {353--371},
  publisher    = {Elsevier Ltd},
  series       = {Frontiers of Nanoscience},
  title        = {Current challenges and coming opportunities in nanoparticle risk assessment},
  url          = {http://dx.doi.org/10.1016/B978-0-08-102828-5.00013-9},
  doi          = {10.1016/B978-0-08-102828-5.00013-9},
  volume       = {16},
  year         = {2020},
}