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Current challenges and coming opportunities in nanoparticle risk assessment

Bondarenko, Olesja M. ; Krais, Annette M. LU orcid and Farrera, Consol (2020) In Frontiers of Nanoscience 16. p.353-371
Abstract

This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the... (More)

This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Nanosafety, Nanotechnology, Nanotoxicology
host publication
Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications - Synthesis, Characterization and Potential Applications
series title
Frontiers of Nanoscience
editor
Parak, Wolfgang J. and Feliu, Neus
volume
16
pages
19 pages
publisher
Elsevier
external identifiers
  • scopus:85083671333
ISSN
1876-2778
1876-276X
ISBN
978-0-08-102828-5
DOI
10.1016/B978-0-08-102828-5.00013-9
language
English
LU publication?
yes
id
178ff4e2-0a7f-44c0-b230-87237c703271
date added to LUP
2020-05-28 16:14:04
date last changed
2024-04-03 08:42:24
@inbook{178ff4e2-0a7f-44c0-b230-87237c703271,
  abstract     = {{<p>This chapter discusses the key aspects of engineered nanomaterial (ENM) toxicity. The individual properties of ENMs affecting their toxic potential are described, with a special focus on size, shape, and surface charge and functionalization. We present empirical evidence from a range of in vitro and in vivo studies showing potential adverse effects induced via inhalation, ingestion, or skin contact with ENMs, as well as a brief overview of human studies and nanoecotoxicology. Finally, a summary of current guidelines and frameworks is provided, together with a collection of the most prominent nanosafety projects and resources available for the assessment of nanotoxicity. This literature review demonstrates that there is a need for the collection of standardized data from human studies to inform epidemiological studies. Moreover, despite the wide usage of ENMs and reported toxic potentials, there is a shortage of policies regulating the exposure and usage of ENMs to protect both the environment and human health.</p>}},
  author       = {{Bondarenko, Olesja M. and Krais, Annette M. and Farrera, Consol}},
  booktitle    = {{Colloids for Nanobiotechnology : Synthesis, Characterization and Potential Applications}},
  editor       = {{Parak, Wolfgang J. and Feliu, Neus}},
  isbn         = {{978-0-08-102828-5}},
  issn         = {{1876-2778}},
  keywords     = {{Nanosafety; Nanotechnology; Nanotoxicology}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{353--371}},
  publisher    = {{Elsevier}},
  series       = {{Frontiers of Nanoscience}},
  title        = {{Current challenges and coming opportunities in nanoparticle risk assessment}},
  url          = {{http://dx.doi.org/10.1016/B978-0-08-102828-5.00013-9}},
  doi          = {{10.1016/B978-0-08-102828-5.00013-9}},
  volume       = {{16}},
  year         = {{2020}},
}