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Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes

Engblom, Henrik LU ; Steding Ehrenborg, Katarina LU ; Carlsson, Marcus LU ; Mosén, Henrik LU ; Hedén, Bo LU ; Buhre, Torsten; Ekmehag, Björn LU and Arheden, Håkan LU (2010) In Journal of Cardiovascular Magnetic Resonance 12.
Abstract
Background: An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO(2)peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO(2)peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by... (More)
Background: An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO(2)peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO(2)peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by maximal exercise test and THV was determined by cardiovascular magnetic resonance. The VO(2)peak/THV ratio was then derived and tested. Results: Peak oxygen uptake was strongly correlated to THV (r(2) = 0.74, p < 0.001) in the control subjects, but not for the patients (r(2) = 0.0002, p = 0.95). The VO(2)peak/THV ratio differed significantly between control subjects and patients, even in patients with normal ejection fraction and after normalizing for hemoglobin levels (p < 0.001). In a multivariate analysis the VO(2)peak/THV ratio was the only independent predictor of presence of HF (p < 0.001). Conclusions: The VO(2)peak/THV ratio can be used to distinguish patients with clinically diagnosed HF from healthy volunteers and athletes, even in patients with preserved systolic left ventricular function and after normalizing for hemoglobin levels. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
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in
Journal of Cardiovascular Magnetic Resonance
volume
12
publisher
BioMed Central
external identifiers
  • wos:000286282600001
  • scopus:79952788320
ISSN
1097-6647
DOI
10.1186/1532-429X-12-74
language
English
LU publication?
yes
id
37c8e03d-db95-4329-8358-810a6ae787b8 (old id 1814766)
date added to LUP
2011-03-02 13:34:52
date last changed
2018-06-17 03:42:34
@article{37c8e03d-db95-4329-8358-810a6ae787b8,
  abstract     = {Background: An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO(2)peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO(2)peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by maximal exercise test and THV was determined by cardiovascular magnetic resonance. The VO(2)peak/THV ratio was then derived and tested. Results: Peak oxygen uptake was strongly correlated to THV (r(2) = 0.74, p &lt; 0.001) in the control subjects, but not for the patients (r(2) = 0.0002, p = 0.95). The VO(2)peak/THV ratio differed significantly between control subjects and patients, even in patients with normal ejection fraction and after normalizing for hemoglobin levels (p &lt; 0.001). In a multivariate analysis the VO(2)peak/THV ratio was the only independent predictor of presence of HF (p &lt; 0.001). Conclusions: The VO(2)peak/THV ratio can be used to distinguish patients with clinically diagnosed HF from healthy volunteers and athletes, even in patients with preserved systolic left ventricular function and after normalizing for hemoglobin levels.},
  author       = {Engblom, Henrik and Steding Ehrenborg, Katarina and Carlsson, Marcus and Mosén, Henrik and Hedén, Bo and Buhre, Torsten and Ekmehag, Björn and Arheden, Håkan},
  issn         = {1097-6647},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal of Cardiovascular Magnetic Resonance},
  title        = {Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes},
  url          = {http://dx.doi.org/10.1186/1532-429X-12-74},
  volume       = {12},
  year         = {2010},
}