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Maternal and child outcome after in-vitro fertilization-a review of 25 years population based data from Sweden.

Finnström, Orvar; Källén, Bengt LU ; Lindam, Anna; Nilsson, Emma; Nygren, Karl-Gösta and Olausson, Petra Otterblad (2011) In Acta Obstetricia et Gynecologica Scandinavica 90(5). p.494-500
Abstract
Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of... (More)
Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of multiple births and preterm births decreased dramatically with a better neonatal outcome, including neonatal mortality. No difference in outcome existed between IVF and ICSI or between the use of fresh and cryopreserved embryos, but children born after blastocyst transfer had a slightly higher risk for preterm birth and congenital malformations than children born after cleavage stage transfer. An increased risk for cerebral palsy, possibly for attention deficit and hyperactivity disorder, for impaired visual acuity, and for childhood cancer was noted but these outcomes were rare also after IVF. An increased risk for asthma was demonstrated. No effect on maternal cancer risk was seen. Conclusions. A marked decrease in multiple births was the main reason for better pregnancy and neonatal outcome and may also have a beneficial effect on long-term results, notably cerebral palsy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
multiple births, morbidity, long-term, neonatal outcome, In vitro fertilization, pregnancy
in
Acta Obstetricia et Gynecologica Scandinavica
volume
90
issue
5
pages
494 - 500
publisher
Wiley-Blackwell
external identifiers
  • wos:000290360100013
  • pmid:21306346
  • scopus:79955060572
ISSN
1600-0412
DOI
10.1111/j.1600-0412.2011.01088.x
language
English
LU publication?
yes
id
e1904598-4f6b-4c3c-bec7-e882572adf80 (old id 1832028)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21306346?dopt=Abstract
date added to LUP
2011-03-01 13:55:39
date last changed
2017-07-09 03:57:31
@article{e1904598-4f6b-4c3c-bec7-e882572adf80,
  abstract     = {Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of multiple births and preterm births decreased dramatically with a better neonatal outcome, including neonatal mortality. No difference in outcome existed between IVF and ICSI or between the use of fresh and cryopreserved embryos, but children born after blastocyst transfer had a slightly higher risk for preterm birth and congenital malformations than children born after cleavage stage transfer. An increased risk for cerebral palsy, possibly for attention deficit and hyperactivity disorder, for impaired visual acuity, and for childhood cancer was noted but these outcomes were rare also after IVF. An increased risk for asthma was demonstrated. No effect on maternal cancer risk was seen. Conclusions. A marked decrease in multiple births was the main reason for better pregnancy and neonatal outcome and may also have a beneficial effect on long-term results, notably cerebral palsy.},
  author       = {Finnström, Orvar and Källén, Bengt and Lindam, Anna and Nilsson, Emma and Nygren, Karl-Gösta and Olausson, Petra Otterblad},
  issn         = {1600-0412},
  keyword      = {multiple births,morbidity,long-term,neonatal outcome,In vitro fertilization,pregnancy},
  language     = {eng},
  number       = {5},
  pages        = {494--500},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Maternal and child outcome after in-vitro fertilization-a review of 25 years population based data from Sweden.},
  url          = {http://dx.doi.org/10.1111/j.1600-0412.2011.01088.x},
  volume       = {90},
  year         = {2011},
}