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Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells.

Jaensson Gyllenbäck, Elin LU ; Kotarsky, Knut LU ; Zapata, Fernando LU ; Persson, E K; Gundersen, T E; Blomhoff, R and Agace, William LU (2011) In Mucosal Immunology 4. p.438-447
Abstract
Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs.... (More)
Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs. Remarkably, SI CD103(+) DCs remained imprinted in mice depleted of dietary but not of systemic retinol. We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-derived DCs, and imprinted these cells with the ability to generate gut-tropic T cells. Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting.Mucosal Immunology advance online publication 2 February 2011. doi:10.1038/mi.2010.91. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mucosal Immunology
volume
4
pages
438 - 447
publisher
Nature Publishing Group
external identifiers
  • wos:000291721500009
  • pmid:21289617
  • scopus:79959396339
ISSN
1933-0219
DOI
10.1038/mi.2010.91
language
English
LU publication?
yes
id
65425a3e-bc7e-4a6d-94d1-ea9e8d6c2f4d (old id 1832316)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21289617?dopt=Abstract
date added to LUP
2011-03-01 11:53:00
date last changed
2017-10-01 04:55:08
@article{65425a3e-bc7e-4a6d-94d1-ea9e8d6c2f4d,
  abstract     = {Small intestinal lamina propria (SI-LP) CD103(+) dendritic cells (DCs) are imprinted with an ability to metabolize vitamin A (retinol), a property underlying their enhanced capacity to induce the gut-homing receptors CC chemokine receptor-9 and α4β7 on responding T cells. In this study, we demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI). The major vitamin A metabolite retinoic acid (RA) induced retinol-metabolizing activity in DCs both in vitro and in vivo, suggesting a direct role for RA in this process. Consistent with this, SI-LP CD103(+) DCs constitutively received RA signals in vivo at significantly higher levels than did colonic CD103(+) DCs. Remarkably, SI CD103(+) DCs remained imprinted in mice depleted of dietary but not of systemic retinol. We found that bile contained high levels of retinol, induced RA receptor-dependent retinol-metabolizing activity in bone marrow-derived DCs, and imprinted these cells with the ability to generate gut-tropic T cells. Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting.Mucosal Immunology advance online publication 2 February 2011. doi:10.1038/mi.2010.91.},
  author       = {Jaensson Gyllenbäck, Elin and Kotarsky, Knut and Zapata, Fernando and Persson, E K and Gundersen, T E and Blomhoff, R and Agace, William},
  issn         = {1933-0219},
  language     = {eng},
  pages        = {438--447},
  publisher    = {Nature Publishing Group},
  series       = {Mucosal Immunology},
  title        = {Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells.},
  url          = {http://dx.doi.org/10.1038/mi.2010.91},
  volume       = {4},
  year         = {2011},
}