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Molecular structure of maltoside surfactants controls micelle formation and rheological behavior

Larsson, Johan LU ; Sanchez-Fernandez, Adrian LU orcid ; Leung, Anna E. ; Schweins, Ralf ; Wu, Baohu ; Nylander, Tommy LU ; Ulvenlund, Stefan LU and Wahlgren, Marie LU orcid (2021) In Journal of Colloid and Interface Science 581. p.895-904
Abstract

Hypothesis: The anomeric configuration (α or β) of n-hexadecyl-D-maltopyranoside (C16G2) has been shown to affect the morphology of the micelle, from elongated for α-C16G2 to worm-like micelles for β-C16G2. The entanglement of worm-like micelles often leads to strong modifications of the rheological behavior of the system and, as such, the anomeric configuration of C16G2 could also provide the possibility of controlling this. Furthermore, mixing these surfactants are hypothesized to result in mixed micelles allowing to finely tune the rheology of a system containing these sustainable surfactants. Experiments: The rheology of α- and... (More)

Hypothesis: The anomeric configuration (α or β) of n-hexadecyl-D-maltopyranoside (C16G2) has been shown to affect the morphology of the micelle, from elongated for α-C16G2 to worm-like micelles for β-C16G2. The entanglement of worm-like micelles often leads to strong modifications of the rheological behavior of the system and, as such, the anomeric configuration of C16G2 could also provide the possibility of controlling this. Furthermore, mixing these surfactants are hypothesized to result in mixed micelles allowing to finely tune the rheology of a system containing these sustainable surfactants. Experiments: The rheology of α- and β-C16G2, and mixtures of those, was determined by rotational and oscillatory rheology at different temperatures and surfactant concentrations. Micelle structure and composition for these systems were characterized using contrast variation small-angle neutron scattering and small-angle X-ray scattering. The results from these were connected in order to elaborate a molecular understanding of the rheological response of the system. Findings: The self-assembly of these surfactants have been found to result in different rheological properties. β-C16G2 show a high viscosity with a non-Newtonian viscoelastic behavior, which was linked to the formation of worm-like micelles. In contrast, α-C16G2 self-assembled into short cylindrical micelles, resulting in a Newtonian fluid with low viscosity. Furthermore, mixtures of these two surfactants lead to systems with intermediate rheological properties as a result of the formation of micelles with intermediate morphology to those of the pure anomers. These results also show that the rheological properties of the system can be tuned to change the micelle morphology, which in turn depends on the anomeric configuration of the surfactant. Also, surfactant concentration, temperature of the system, and micelle composition for surfactant mixtures provide control over the rheological properties of the system in a wide temperature range. Therefore, these results open new possibilities in the development of sustainable excipients for formulation technology, where the characteristics of the system can be easily tailored through geometric variations in the monomer structure whilst maintaining the chemical composition of the system.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alkylglycoside, Rheology, Small-angle neutron scattering, Sugar-based surfactant, Viscoelastic, Worm-like micelle
in
Journal of Colloid and Interface Science
volume
581
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:85091044064
  • pmid:32950938
ISSN
0021-9797
DOI
10.1016/j.jcis.2020.08.116
project
Tailoring the self-assembly, interfacial properties and rheological behaviour of sugar-based surfactants
language
English
LU publication?
yes
id
185ad1f3-81a6-4a54-be5b-95d0f26886b8
date added to LUP
2020-09-29 15:51:01
date last changed
2024-02-16 23:18:25
@article{185ad1f3-81a6-4a54-be5b-95d0f26886b8,
  abstract     = {{<p>Hypothesis: The anomeric configuration (α or β) of n-hexadecyl-D-maltopyranoside (C<sub>16</sub>G<sub>2</sub>) has been shown to affect the morphology of the micelle, from elongated for α-C<sub>16</sub>G<sub>2</sub> to worm-like micelles for β-C<sub>16</sub>G<sub>2</sub>. The entanglement of worm-like micelles often leads to strong modifications of the rheological behavior of the system and, as such, the anomeric configuration of C<sub>16</sub>G<sub>2</sub> could also provide the possibility of controlling this. Furthermore, mixing these surfactants are hypothesized to result in mixed micelles allowing to finely tune the rheology of a system containing these sustainable surfactants. Experiments: The rheology of α- and β-C<sub>16</sub>G<sub>2</sub>, and mixtures of those, was determined by rotational and oscillatory rheology at different temperatures and surfactant concentrations. Micelle structure and composition for these systems were characterized using contrast variation small-angle neutron scattering and small-angle X-ray scattering. The results from these were connected in order to elaborate a molecular understanding of the rheological response of the system. Findings: The self-assembly of these surfactants have been found to result in different rheological properties. β-C<sub>16</sub>G<sub>2</sub> show a high viscosity with a non-Newtonian viscoelastic behavior, which was linked to the formation of worm-like micelles. In contrast, α-C<sub>16</sub>G<sub>2</sub> self-assembled into short cylindrical micelles, resulting in a Newtonian fluid with low viscosity. Furthermore, mixtures of these two surfactants lead to systems with intermediate rheological properties as a result of the formation of micelles with intermediate morphology to those of the pure anomers. These results also show that the rheological properties of the system can be tuned to change the micelle morphology, which in turn depends on the anomeric configuration of the surfactant. Also, surfactant concentration, temperature of the system, and micelle composition for surfactant mixtures provide control over the rheological properties of the system in a wide temperature range. Therefore, these results open new possibilities in the development of sustainable excipients for formulation technology, where the characteristics of the system can be easily tailored through geometric variations in the monomer structure whilst maintaining the chemical composition of the system.</p>}},
  author       = {{Larsson, Johan and Sanchez-Fernandez, Adrian and Leung, Anna E. and Schweins, Ralf and Wu, Baohu and Nylander, Tommy and Ulvenlund, Stefan and Wahlgren, Marie}},
  issn         = {{0021-9797}},
  keywords     = {{Alkylglycoside; Rheology; Small-angle neutron scattering; Sugar-based surfactant; Viscoelastic; Worm-like micelle}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{895--904}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Colloid and Interface Science}},
  title        = {{Molecular structure of maltoside surfactants controls micelle formation and rheological behavior}},
  url          = {{http://dx.doi.org/10.1016/j.jcis.2020.08.116}},
  doi          = {{10.1016/j.jcis.2020.08.116}},
  volume       = {{581}},
  year         = {{2021}},
}