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Apparent exchange rate mapping with diffusion MRI.

Lasic, Samo LU ; Nilsson, Markus LU ; Lätt, Jimmy LU ; Ståhlberg, Freddy LU and Topgaard, Daniel LU (2011) In Magnetic Resonance in Medicine 66. p.356-365
Abstract
Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and ischemic stroke, expected to be associated with a change of the membrane barrier properties. This study describes the filter exchange imaging method for determining the rate of water exchange between sites having different apparent diffusion coefficients. The method is based on the filter-exchange pulsed gradient spin-echo NMR spectroscopy... (More)
Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and ischemic stroke, expected to be associated with a change of the membrane barrier properties. This study describes the filter exchange imaging method for determining the rate of water exchange between sites having different apparent diffusion coefficients. The method is based on the filter-exchange pulsed gradient spin-echo NMR spectroscopy experiment, which is here modified to be compatible with the constraints of clinical MR scanners. The data is analyzed using a model-free approach yielding maps of the apparent exchange rate, here being introduced in analogy with the concept of the apparent diffusion coefficient. Proof-of-principle experiments are performed on microimaging and whole-body clinical scanners using yeast suspension phantoms. The limitations and appropriate experimental conditions are examined. The results demonstrate that filter exchange imaging is a fast and reliable method for characterizing exchange, and that it has the potential to become a powerful diagnostic tool. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
66
pages
356 - 365
publisher
Wiley Online Library
external identifiers
  • wos:000293256800007
  • pmid:21446037
  • scopus:79960575680
ISSN
1522-2594
DOI
10.1002/mrm.22782
language
English
LU publication?
yes
id
2dcc1895-222f-4d56-b86b-912b24313af0 (old id 1883331)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21446037?dopt=Abstract
date added to LUP
2011-04-01 22:30:45
date last changed
2017-07-09 04:35:07
@article{2dcc1895-222f-4d56-b86b-912b24313af0,
  abstract     = {Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and ischemic stroke, expected to be associated with a change of the membrane barrier properties. This study describes the filter exchange imaging method for determining the rate of water exchange between sites having different apparent diffusion coefficients. The method is based on the filter-exchange pulsed gradient spin-echo NMR spectroscopy experiment, which is here modified to be compatible with the constraints of clinical MR scanners. The data is analyzed using a model-free approach yielding maps of the apparent exchange rate, here being introduced in analogy with the concept of the apparent diffusion coefficient. Proof-of-principle experiments are performed on microimaging and whole-body clinical scanners using yeast suspension phantoms. The limitations and appropriate experimental conditions are examined. The results demonstrate that filter exchange imaging is a fast and reliable method for characterizing exchange, and that it has the potential to become a powerful diagnostic tool. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.},
  author       = {Lasic, Samo and Nilsson, Markus and Lätt, Jimmy and Ståhlberg, Freddy and Topgaard, Daniel},
  issn         = {1522-2594},
  language     = {eng},
  pages        = {356--365},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Apparent exchange rate mapping with diffusion MRI.},
  url          = {http://dx.doi.org/10.1002/mrm.22782},
  volume       = {66},
  year         = {2011},
}