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Physiological functions and clinical implications of sphingolipids in the gut.

Duan, Rui-Dong LU (2011) In Journal of Digestive Diseases 12(2). p.60-70
Abstract
Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and... (More)
Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and tumor development in the gut. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Digestive Diseases
volume
12
issue
2
pages
60 - 70
publisher
Wiley-Blackwell
external identifiers
  • wos:000288458600002
  • pmid:21401891
  • scopus:79952684482
ISSN
1751-2972
DOI
10.1111/j.1751-2980.2011.00481.x
language
English
LU publication?
yes
id
ad019874-f3e5-4d26-9df3-6e6f8dbad3a1 (old id 1883981)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21401891?dopt=Abstract
date added to LUP
2011-04-01 15:44:54
date last changed
2017-08-20 04:39:15
@article{ad019874-f3e5-4d26-9df3-6e6f8dbad3a1,
  abstract     = {Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and tumor development in the gut.},
  author       = {Duan, Rui-Dong},
  issn         = {1751-2972},
  language     = {eng},
  number       = {2},
  pages        = {60--70},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Digestive Diseases},
  title        = {Physiological functions and clinical implications of sphingolipids in the gut.},
  url          = {http://dx.doi.org/10.1111/j.1751-2980.2011.00481.x},
  volume       = {12},
  year         = {2011},
}