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Seizure-induced neurogenesis in the adult brain.

Kokaia, Merab LU (2011) In European Journal of Neuroscience 33(6). p.1133-1138
Abstract
It is well established that seizures increase adult neurogenesis in the subventricular and subgranular zones, the most neurogenic regions of the adult rodent and apparently human brain. However, the role of increased neurogenesis in these areas in seizure generation (ictogenesis) and epileptogenesis remains elusive. It is of utmost importance to explore how the cells that are born in response to epileptic seizures are functionally integrated into the existing neuronal networks, and how this integration would contribute to the excitability of this network. This will determine whether increased neurogenesis is beneficial or counteractive to ictogenesis and epileptogenesis. Some of the crucial factors affecting the functional integration of... (More)
It is well established that seizures increase adult neurogenesis in the subventricular and subgranular zones, the most neurogenic regions of the adult rodent and apparently human brain. However, the role of increased neurogenesis in these areas in seizure generation (ictogenesis) and epileptogenesis remains elusive. It is of utmost importance to explore how the cells that are born in response to epileptic seizures are functionally integrated into the existing neuronal networks, and how this integration would contribute to the excitability of this network. This will determine whether increased neurogenesis is beneficial or counteractive to ictogenesis and epileptogenesis. Some of the crucial factors affecting the functional integration of newborn cells seem to be excessive neuronal activity and/or inflammatory microenvironment, both associated with acute, as well as chronic, epileptic conditions. This review will focus on aspects of the functional integration of newborn cells in animal models of epilepsy with various degrees of seizure severity and associated microenvironmental alterations in the brain tissue. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Neuroscience
volume
33
issue
6
pages
1133 - 1138
publisher
Wiley-Blackwell
external identifiers
  • wos:000288384700015
  • pmid:21395857
  • scopus:79952603835
ISSN
1460-9568
DOI
10.1111/j.1460-9568.2011.07612.x
language
English
LU publication?
yes
id
3a18322e-bda6-496b-a9d6-aaf37ee8f012 (old id 1884065)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21395857?dopt=Abstract
date added to LUP
2011-04-01 15:19:09
date last changed
2017-07-30 04:50:22
@article{3a18322e-bda6-496b-a9d6-aaf37ee8f012,
  abstract     = {It is well established that seizures increase adult neurogenesis in the subventricular and subgranular zones, the most neurogenic regions of the adult rodent and apparently human brain. However, the role of increased neurogenesis in these areas in seizure generation (ictogenesis) and epileptogenesis remains elusive. It is of utmost importance to explore how the cells that are born in response to epileptic seizures are functionally integrated into the existing neuronal networks, and how this integration would contribute to the excitability of this network. This will determine whether increased neurogenesis is beneficial or counteractive to ictogenesis and epileptogenesis. Some of the crucial factors affecting the functional integration of newborn cells seem to be excessive neuronal activity and/or inflammatory microenvironment, both associated with acute, as well as chronic, epileptic conditions. This review will focus on aspects of the functional integration of newborn cells in animal models of epilepsy with various degrees of seizure severity and associated microenvironmental alterations in the brain tissue.},
  author       = {Kokaia, Merab},
  issn         = {1460-9568},
  language     = {eng},
  number       = {6},
  pages        = {1133--1138},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Seizure-induced neurogenesis in the adult brain.},
  url          = {http://dx.doi.org/10.1111/j.1460-9568.2011.07612.x},
  volume       = {33},
  year         = {2011},
}