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Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α(1)-microglobulin.

May, K; Wester Rosenlöf, Lena; Gram, Magnus LU ; Centlow, Magnus; Mörgelin, Matthias LU ; Larsson, Irene LU ; Cederlund, Martin LU ; Rutardottir, Sigurbjörg LU ; Siegmund, W and Schneider, H, et al. (2011) In Placenta 32(4). p.323-332
Abstract
Preeclamptic women have increased plasma levels of free fetal hemoglobin (HbF), increased gene expression of placental HbF and accumulation of free HbF in the placental vascular lumen. Free hemoglobin (Hb) is pro-inflammatory, and causes oxidative stress and tissue damage.
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Oxidative stress, Hemoglobin, Dual placental perfusion, Microarray, Electron microscopy, alpha(1)-microglobulin
in
Placenta
volume
32
issue
4
pages
323 - 332
publisher
W B Saunders
external identifiers
  • wos:000289393500005
  • pmid:21356557
  • scopus:79952738574
ISSN
1532-3102
DOI
10.1016/j.placenta.2011.01.017
language
English
LU publication?
yes
id
9f829aed-3386-46c2-bd65-9b3bef28185b (old id 1884552)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21356557?dopt=Abstract
date added to LUP
2011-04-01 11:40:06
date last changed
2017-07-23 03:21:56
@article{9f829aed-3386-46c2-bd65-9b3bef28185b,
  abstract     = {Preeclamptic women have increased plasma levels of free fetal hemoglobin (HbF), increased gene expression of placental HbF and accumulation of free HbF in the placental vascular lumen. Free hemoglobin (Hb) is pro-inflammatory, and causes oxidative stress and tissue damage.},
  author       = {May, K and Wester Rosenlöf, Lena and Gram, Magnus and Centlow, Magnus and Mörgelin, Matthias and Larsson, Irene and Cederlund, Martin and Rutardottir, Sigurbjörg and Siegmund, W and Schneider, H and Åkerström, Bo and Hansson, Stefan},
  issn         = {1532-3102},
  keyword      = {Oxidative stress,Hemoglobin,Dual placental perfusion,Microarray,Electron microscopy,alpha(1)-microglobulin},
  language     = {eng},
  number       = {4},
  pages        = {323--332},
  publisher    = {W B Saunders},
  series       = {Placenta},
  title        = {Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α(1)-microglobulin.},
  url          = {http://dx.doi.org/10.1016/j.placenta.2011.01.017},
  volume       = {32},
  year         = {2011},
}