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Does the time interval between first and last birth influence the risk of endometrial and ovarian cancer?

Bevier, Melanie; Sundquist, Jan LU and Hemminki, Kari LU (2011) In European Journal of Cancer 47(4). p.586-591
Abstract
Background: Age at first and last birth and the number of children are known to influence the risk of endometrial and ovarian cancers. However, it remains unknown whether the difference in years between first and last childbirth plays a role. The Swedish Family-Cancer Database allowed us to carry out the largest study ever on reproductive factors in these cancers. Material and methods: We selected over 5.7 million women from the database. We estimated the effect of number of children, age at birth and difference between age at first and last birth by Poisson regression adjusted for age, period, region and socioeconomic status. Results: The risk for endometrial cancer is negatively associated with increasing number of children and... (More)
Background: Age at first and last birth and the number of children are known to influence the risk of endometrial and ovarian cancers. However, it remains unknown whether the difference in years between first and last childbirth plays a role. The Swedish Family-Cancer Database allowed us to carry out the largest study ever on reproductive factors in these cancers. Material and methods: We selected over 5.7 million women from the database. We estimated the effect of number of children, age at birth and difference between age at first and last birth by Poisson regression adjusted for age, period, region and socioeconomic status. Results: The risk for endometrial cancer is negatively associated with increasing number of children and increasing age at first as well as age at last birth. Weaker associations are found for ovarian cancer. Age at last birth is the factor that shows highest influence. A large difference in first and last childbirth shows a protective effect on the risk of endometrial cancer. Conclusion: Our findings suggest that the risk of endometrial cancer is significantly decreased for women having at least a difference of 10 years between their first and last birth. Ovarian cancer does not seem to be influenced by the time interval between first and last birth. (c) 2010 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endometrial cancer, Ovarian cancer, Cancer risk, Reproductive factors
in
European Journal of Cancer
volume
47
issue
4
pages
586 - 591
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000288468700013
  • scopus:79851511707
ISSN
1879-0852
DOI
10.1016/j.ejca.2010.10.004
language
English
LU publication?
yes
id
cec4a7ea-07b4-4d9d-b445-48a079acec94 (old id 1936297)
date added to LUP
2011-05-02 07:53:23
date last changed
2017-11-05 03:06:06
@article{cec4a7ea-07b4-4d9d-b445-48a079acec94,
  abstract     = {Background: Age at first and last birth and the number of children are known to influence the risk of endometrial and ovarian cancers. However, it remains unknown whether the difference in years between first and last childbirth plays a role. The Swedish Family-Cancer Database allowed us to carry out the largest study ever on reproductive factors in these cancers. Material and methods: We selected over 5.7 million women from the database. We estimated the effect of number of children, age at birth and difference between age at first and last birth by Poisson regression adjusted for age, period, region and socioeconomic status. Results: The risk for endometrial cancer is negatively associated with increasing number of children and increasing age at first as well as age at last birth. Weaker associations are found for ovarian cancer. Age at last birth is the factor that shows highest influence. A large difference in first and last childbirth shows a protective effect on the risk of endometrial cancer. Conclusion: Our findings suggest that the risk of endometrial cancer is significantly decreased for women having at least a difference of 10 years between their first and last birth. Ovarian cancer does not seem to be influenced by the time interval between first and last birth. (c) 2010 Elsevier Ltd. All rights reserved.},
  author       = {Bevier, Melanie and Sundquist, Jan and Hemminki, Kari},
  issn         = {1879-0852},
  keyword      = {Endometrial cancer,Ovarian cancer,Cancer risk,Reproductive factors},
  language     = {eng},
  number       = {4},
  pages        = {586--591},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Does the time interval between first and last birth influence the risk of endometrial and ovarian cancer?},
  url          = {http://dx.doi.org/10.1016/j.ejca.2010.10.004},
  volume       = {47},
  year         = {2011},
}