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Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.

Sterner, Y; Törn, Carina LU ; Lee, H-S; Larsson, Helena LU ; Winkler, Christian LU ; McLeod, W; Lynch, Kristian LU ; Simell, O; Ziegler, A and Schatz, D, et al. (2011) In Journal of Perinatology 31. p.764-769
Abstract
Objective:To examine the relationship between high-risk human leukocyte antigen (HLA) genotypes for type 1 diabetes and birth size in combination with prenatal characteristics in different countries.Study Design:Four high-risk HLA genotypes were enrolled in the Environmental determinants of Diabetes in the Young study newborn babies from the general population in Finland, Germany, Sweden and the United States. Stepwise regression analyses were used to adjust for country, parental physical characteristics and environmental factors during pregnancy.Result:Regression analyses did not reveal differences in birth size between the four type 1 diabetes high-risk HLA genotypes. Compared with DQ 4/8 in each country, (1) DQ 2/2 children were heavier... (More)
Objective:To examine the relationship between high-risk human leukocyte antigen (HLA) genotypes for type 1 diabetes and birth size in combination with prenatal characteristics in different countries.Study Design:Four high-risk HLA genotypes were enrolled in the Environmental determinants of Diabetes in the Young study newborn babies from the general population in Finland, Germany, Sweden and the United States. Stepwise regression analyses were used to adjust for country, parental physical characteristics and environmental factors during pregnancy.Result:Regression analyses did not reveal differences in birth size between the four type 1 diabetes high-risk HLA genotypes. Compared with DQ 4/8 in each country, (1) DQ 2/2 children were heavier in the United States (P=0.028) mostly explained however, by parental weight; (2) DQ 2/8 (P=0.023) and DQ 8/8 (P=0.046) children were longer in Sweden independent of parents height and as well as (3) in the United States for DQ 2/8 (P=0.023), but again dependent on parental height.Conclusion:Children born with type 1 diabetes high-risk HLA genotypes have comparable birth size. Longitudinal follow-up of these children should reveal whether birth size differences between countries contribute to the risk for islet autoimmunity and type 1 diabetes.Journal of Perinatology advance online publication, 28 April 2011; doi:10.1038/jp.2011.26. (Less)
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Journal of Perinatology
volume
31
pages
764 - 769
publisher
Nature Publishing Group
external identifiers
  • wos:000297646000005
  • pmid:21527903
  • scopus:82455171831
ISSN
0743-8346
DOI
10.1038/jp.2011.26
language
English
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yes
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6f65cef4-9ec9-4c68-aab2-2e49bf89a80d (old id 1936603)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21527903?dopt=Abstract
date added to LUP
2011-05-02 17:08:53
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2017-01-01 04:12:04
@article{6f65cef4-9ec9-4c68-aab2-2e49bf89a80d,
  abstract     = {Objective:To examine the relationship between high-risk human leukocyte antigen (HLA) genotypes for type 1 diabetes and birth size in combination with prenatal characteristics in different countries.Study Design:Four high-risk HLA genotypes were enrolled in the Environmental determinants of Diabetes in the Young study newborn babies from the general population in Finland, Germany, Sweden and the United States. Stepwise regression analyses were used to adjust for country, parental physical characteristics and environmental factors during pregnancy.Result:Regression analyses did not reveal differences in birth size between the four type 1 diabetes high-risk HLA genotypes. Compared with DQ 4/8 in each country, (1) DQ 2/2 children were heavier in the United States (P=0.028) mostly explained however, by parental weight; (2) DQ 2/8 (P=0.023) and DQ 8/8 (P=0.046) children were longer in Sweden independent of parents height and as well as (3) in the United States for DQ 2/8 (P=0.023), but again dependent on parental height.Conclusion:Children born with type 1 diabetes high-risk HLA genotypes have comparable birth size. Longitudinal follow-up of these children should reveal whether birth size differences between countries contribute to the risk for islet autoimmunity and type 1 diabetes.Journal of Perinatology advance online publication, 28 April 2011; doi:10.1038/jp.2011.26.},
  author       = {Sterner, Y and Törn, Carina and Lee, H-S and Larsson, Helena and Winkler, Christian and McLeod, W and Lynch, Kristian and Simell, O and Ziegler, A and Schatz, D and Hagopian, W and Rewers, M and She, J-X and Krischer, J P and Akolkar, B and Lernmark, Åke},
  issn         = {0743-8346},
  language     = {eng},
  pages        = {764--769},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Perinatology},
  title        = {Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics.},
  url          = {http://dx.doi.org/10.1038/jp.2011.26},
  volume       = {31},
  year         = {2011},
}