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Early probiotic supplementation and the risk of celiac disease in children at genetic risk

Uusitalo, Ulla ; Aronsson, Carin Andren LU ; Liu, Xiang ; Kurppa, Kalle ; Yang, Jimin ; Liu, Edwin ; Skidmore, Jennifer ; Winkler, Christiane ; Rewers, Marian J. and Hagopian, William A. , et al. (2019) In Nutrients 11(8).
Abstract

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk... (More)

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.

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type
Contribution to journal
publication status
published
subject
keywords
Celiac disease, Celiac disease autoimmunity, Dietary supplements, Infant formula, Probiotics
in
Nutrients
volume
11
issue
8
article number
1790
publisher
MDPI AG
external identifiers
  • scopus:85070811472
  • pmid:31382440
ISSN
2072-6643
DOI
10.3390/nu11081790
language
English
LU publication?
yes
id
19690cd4-5a87-451b-a180-452aa8a3c87a
date added to LUP
2019-09-06 15:43:31
date last changed
2021-05-05 04:02:38
@article{19690cd4-5a87-451b-a180-452aa8a3c87a,
  abstract     = {<p>Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.</p>},
  author       = {Uusitalo, Ulla and Aronsson, Carin Andren and Liu, Xiang and Kurppa, Kalle and Yang, Jimin and Liu, Edwin and Skidmore, Jennifer and Winkler, Christiane and Rewers, Marian J. and Hagopian, William A. and She, Jin Xiong and Toppari, Jorma and Ziegler, Anette G. and Akolkar, Beena and Norris, Jill M. and Virtanen, Suvi M. and Krischer, Jeffrey P. and Agardh, Daniel},
  issn         = {2072-6643},
  language     = {eng},
  month        = {08},
  number       = {8},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Early probiotic supplementation and the risk of celiac disease in children at genetic risk},
  url          = {http://dx.doi.org/10.3390/nu11081790},
  doi          = {10.3390/nu11081790},
  volume       = {11},
  year         = {2019},
}