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Soft tissue response to titanium dioxide nanotube modified implants.

Smith, Garrett LU ; Chamberlain, Lisa; Faxius, Linda LU ; Johnston, Gary W; Jin, Sungho and Bjursten, Lars Magnus LU (2011) In Acta Biomaterialia 7. p.3209-3215
Abstract
Titanium is widely used clinically, yet little is known regarding the effects of modifying its three-dimensional surface geometry at the nanoscale level. In this project we have explored the in vivo response in terms of nitric oxide scavenging and fibrotic capsule formation to nano-modified titanium implant surfaces. We compared titanium dioxide (TiO(2)) nanotubes with 100nm diameters fabricated by electrochemical anodization with TiO(2) control surfaces. Significantly lower nitric oxide was observed for the nanostructured surface in solution, suggesting that nanotubes break down nitric oxide. To evaluate the soft tissue response in vivo TiO(2) nanotube and TiO(2) control implants were placed in the rat abdominal wall for 1 and 6weeks. A... (More)
Titanium is widely used clinically, yet little is known regarding the effects of modifying its three-dimensional surface geometry at the nanoscale level. In this project we have explored the in vivo response in terms of nitric oxide scavenging and fibrotic capsule formation to nano-modified titanium implant surfaces. We compared titanium dioxide (TiO(2)) nanotubes with 100nm diameters fabricated by electrochemical anodization with TiO(2) control surfaces. Significantly lower nitric oxide was observed for the nanostructured surface in solution, suggesting that nanotubes break down nitric oxide. To evaluate the soft tissue response in vivo TiO(2) nanotube and TiO(2) control implants were placed in the rat abdominal wall for 1 and 6weeks. A reduced fibrotic capsule thickness was observed for the nanotube surfaces for both time points. Significantly lower nitric oxide activity, measured as the presence of nitrotyrosine (P<0.05), was observed on the nanotube surface after 1week, indicating that the reactive nitrogen species interaction is of importance. The differences observed between the titanium surfaces may be due to the catalytic properties of TiO(2), which are increased by the nanotube structure. These findings may be significant for the interaction between titanium implants in soft tissue as well as bone tissue and provide a mechanism by which to improve future clinical implants. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Biomaterialia
volume
7
pages
3209 - 3215
publisher
Elsevier
external identifiers
  • wos:000293259500022
  • pmid:21601662
  • scopus:79959825308
ISSN
1878-7568
DOI
10.1016/j.actbio.2011.05.003
language
English
LU publication?
yes
id
2577f2c8-fdfa-43a5-936f-2665b1efc15f (old id 1972265)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21601662?dopt=Abstract
date added to LUP
2011-06-07 21:55:02
date last changed
2017-05-21 04:34:51
@article{2577f2c8-fdfa-43a5-936f-2665b1efc15f,
  abstract     = {Titanium is widely used clinically, yet little is known regarding the effects of modifying its three-dimensional surface geometry at the nanoscale level. In this project we have explored the in vivo response in terms of nitric oxide scavenging and fibrotic capsule formation to nano-modified titanium implant surfaces. We compared titanium dioxide (TiO(2)) nanotubes with 100nm diameters fabricated by electrochemical anodization with TiO(2) control surfaces. Significantly lower nitric oxide was observed for the nanostructured surface in solution, suggesting that nanotubes break down nitric oxide. To evaluate the soft tissue response in vivo TiO(2) nanotube and TiO(2) control implants were placed in the rat abdominal wall for 1 and 6weeks. A reduced fibrotic capsule thickness was observed for the nanotube surfaces for both time points. Significantly lower nitric oxide activity, measured as the presence of nitrotyrosine (P&lt;0.05), was observed on the nanotube surface after 1week, indicating that the reactive nitrogen species interaction is of importance. The differences observed between the titanium surfaces may be due to the catalytic properties of TiO(2), which are increased by the nanotube structure. These findings may be significant for the interaction between titanium implants in soft tissue as well as bone tissue and provide a mechanism by which to improve future clinical implants.},
  author       = {Smith, Garrett and Chamberlain, Lisa and Faxius, Linda and Johnston, Gary W and Jin, Sungho and Bjursten, Lars Magnus},
  issn         = {1878-7568},
  language     = {eng},
  pages        = {3209--3215},
  publisher    = {Elsevier},
  series       = {Acta Biomaterialia},
  title        = {Soft tissue response to titanium dioxide nanotube modified implants.},
  url          = {http://dx.doi.org/10.1016/j.actbio.2011.05.003},
  volume       = {7},
  year         = {2011},
}