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Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours.

van Westen, Danielle LU ; Petersen, Esben T; Wirestam, Ronnie LU ; Siemund, Roger LU ; Markenroth Bloch, Karin LU ; Ståhlberg, Freddy LU ; Björkman-Burtscher, Isabella LU and Knutsson, Linda LU (2011) In Magma 24. p.211-223
Abstract
OBJECTIVE: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours. MATERIALS AND METHODS: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were... (More)
OBJECTIVE: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours. MATERIALS AND METHODS: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated. RESULTS: In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R (2) was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas. CONCLUSION: These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magma
volume
24
pages
211 - 223
publisher
Springer
external identifiers
  • wos:000295178100003
  • pmid:21594585
  • scopus:80052444399
ISSN
1352-8661
DOI
10.1007/s10334-011-0255-x
language
English
LU publication?
yes
id
e0fb94bb-4cb1-47d2-b12f-184a389e6685 (old id 1972335)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21594585?dopt=Abstract
date added to LUP
2011-06-07 21:43:35
date last changed
2017-05-28 04:14:33
@article{e0fb94bb-4cb1-47d2-b12f-184a389e6685,
  abstract     = {OBJECTIVE: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours. MATERIALS AND METHODS: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated. RESULTS: In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R (2) was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas. CONCLUSION: These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.},
  author       = {van Westen, Danielle and Petersen, Esben T and Wirestam, Ronnie and Siemund, Roger and Markenroth Bloch, Karin and Ståhlberg, Freddy and Björkman-Burtscher, Isabella and Knutsson, Linda},
  issn         = {1352-8661},
  language     = {eng},
  pages        = {211--223},
  publisher    = {Springer},
  series       = {Magma},
  title        = {Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours.},
  url          = {http://dx.doi.org/10.1007/s10334-011-0255-x},
  volume       = {24},
  year         = {2011},
}