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Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.

Lindgren, Ola LU ; Carr, R; Holst, Jan LU ; Deacon, C and Ahrén, Bo LU (2011) In Diabetes, Obesity and Metabolism 13. p.863-865
Abstract
Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in... (More)
Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes, Obesity and Metabolism
volume
13
pages
863 - 865
publisher
Wiley-Blackwell
external identifiers
  • wos:000293179200012
  • pmid:21554523
  • scopus:79960823117
ISSN
1462-8902
DOI
10.1111/j.1463-1326.2011.01420.x
language
English
LU publication?
yes
id
ac1c843c-dfc5-47f5-a001-d2f082dc09f3 (old id 1973052)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21554523?dopt=Abstract
date added to LUP
2011-06-07 14:56:48
date last changed
2017-08-06 04:48:27
@article{ac1c843c-dfc5-47f5-a001-d2f082dc09f3,
  abstract     = {Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion.},
  author       = {Lindgren, Ola and Carr, R and Holst, Jan and Deacon, C and Ahrén, Bo},
  issn         = {1462-8902},
  language     = {eng},
  pages        = {863--865},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetes, Obesity and Metabolism},
  title        = {Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.},
  url          = {http://dx.doi.org/10.1111/j.1463-1326.2011.01420.x},
  volume       = {13},
  year         = {2011},
}