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Fetal hemoglobin and alpha(1)-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia

Dolberg Anderson, Ulrik LU ; Gram, Magnus LU ; Rutardottir, Sigurbjörg LU ; Centlow, Magnus LU ; Kristensen, Karl LU ; Isberg, Per-Erik LU ; Thilaganathan, Baskaran; Åkerström, Bo LU and Hansson, Stefan LU (2011) In American Journal of Obstetrics and Gynecology 204(6).
Abstract
OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and... (More)
OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha(1)-microglobulin, first-trimester biomarker, free fetal, hemoglobin, prediction preeclampsia
in
American Journal of Obstetrics and Gynecology
volume
204
issue
6
publisher
Elsevier
external identifiers
  • wos:000291477300031
  • pmid:21439542
  • scopus:79958082137
ISSN
1097-6868
DOI
10.1016/j.ajog.2011.01.058
language
English
LU publication?
yes
id
7db11eb0-af68-44c3-9757-9f45eb1e66c4 (old id 1985100)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21439542?dopt=Abstract
date added to LUP
2011-07-01 09:10:00
date last changed
2017-11-12 03:06:35
@article{7db11eb0-af68-44c3-9757-9f45eb1e66c4,
  abstract     = {OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and alpha(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P &lt; .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE.},
  author       = {Dolberg Anderson, Ulrik and Gram, Magnus and Rutardottir, Sigurbjörg and Centlow, Magnus and Kristensen, Karl and Isberg, Per-Erik and Thilaganathan, Baskaran and Åkerström, Bo and Hansson, Stefan},
  issn         = {1097-6868},
  keyword      = {alpha(1)-microglobulin,first-trimester biomarker,free fetal,hemoglobin,prediction preeclampsia},
  language     = {eng},
  number       = {6},
  publisher    = {Elsevier},
  series       = {American Journal of Obstetrics and Gynecology},
  title        = {Fetal hemoglobin and alpha(1)-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia},
  url          = {http://dx.doi.org/10.1016/j.ajog.2011.01.058},
  volume       = {204},
  year         = {2011},
}