Advanced

Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer's disease

Gerhardsson, Lars; Lundh, Thomas LU ; Londos, Elisabet LU and Minthon, Lennart LU (2011) In Journal of Neural Transmission 118(6). p.957-962
Abstract
In this study, the quotients (Q) between metal concentrations in cerebrospinal fluid (CSF) and plasma were studied in subjects with Alzheimer's disease (AD) and referents to investigate if the leakage through the blood-CSF barrier (BCB) increased with increased duration and severity of the disease. Concentrations of 18 metals (Mg, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg, and Pb) were determined by ICP-MS in plasma and cerebrospinal fluid in 264 patients with AD, and in 54 healthy referents. The quotients Q (Mn), Q (Rb), Q (Sb), Q (Pb) and Q (Hg) were significantly lower (p a parts per thousand currency sign 0.003) and Q (Co) significantly higher (p a parts per thousand currency sign 0.001) in subjects with AD as... (More)
In this study, the quotients (Q) between metal concentrations in cerebrospinal fluid (CSF) and plasma were studied in subjects with Alzheimer's disease (AD) and referents to investigate if the leakage through the blood-CSF barrier (BCB) increased with increased duration and severity of the disease. Concentrations of 18 metals (Mg, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg, and Pb) were determined by ICP-MS in plasma and cerebrospinal fluid in 264 patients with AD, and in 54 healthy referents. The quotients Q (Mn), Q (Rb), Q (Sb), Q (Pb) and Q (Hg) were significantly lower (p a parts per thousand currency sign 0.003) and Q (Co) significantly higher (p a parts per thousand currency sign 0.001) in subjects with AD as compared with the controls. Subjects in a subgroup with more severe AD, showed the same pattern. The metal leakage into CSF did not increase with increased duration and/or severity of the disease. The permeability of BCB varied considerably between the studied metals with low median quotients (Q a parts per thousand currency sign 0.02) for Cd, Cu, Sb, Se and Zn and higher median quotients for Ca (Q similar to 0.5) and Mg (Q similar to 1.3), probably partly depending on differences in size and lipophilicity of metal-carrier complexes and specific carrier mechanisms. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Blood-CSF barrier, Metals, Blood, Cerebrospinal, fluid
in
Journal of Neural Transmission
volume
118
issue
6
pages
957 - 962
publisher
Springer
external identifiers
  • wos:000291062000012
  • scopus:80051663716
ISSN
0300-9564
DOI
10.1007/s00702-011-0605-x
language
English
LU publication?
yes
id
ec5ae183-601d-4424-9d94-dc1e462031d5 (old id 1985904)
date added to LUP
2011-07-06 11:50:56
date last changed
2017-01-01 06:14:06
@article{ec5ae183-601d-4424-9d94-dc1e462031d5,
  abstract     = {In this study, the quotients (Q) between metal concentrations in cerebrospinal fluid (CSF) and plasma were studied in subjects with Alzheimer's disease (AD) and referents to investigate if the leakage through the blood-CSF barrier (BCB) increased with increased duration and severity of the disease. Concentrations of 18 metals (Mg, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg, and Pb) were determined by ICP-MS in plasma and cerebrospinal fluid in 264 patients with AD, and in 54 healthy referents. The quotients Q (Mn), Q (Rb), Q (Sb), Q (Pb) and Q (Hg) were significantly lower (p a parts per thousand currency sign 0.003) and Q (Co) significantly higher (p a parts per thousand currency sign 0.001) in subjects with AD as compared with the controls. Subjects in a subgroup with more severe AD, showed the same pattern. The metal leakage into CSF did not increase with increased duration and/or severity of the disease. The permeability of BCB varied considerably between the studied metals with low median quotients (Q a parts per thousand currency sign 0.02) for Cd, Cu, Sb, Se and Zn and higher median quotients for Ca (Q similar to 0.5) and Mg (Q similar to 1.3), probably partly depending on differences in size and lipophilicity of metal-carrier complexes and specific carrier mechanisms.},
  author       = {Gerhardsson, Lars and Lundh, Thomas and Londos, Elisabet and Minthon, Lennart},
  issn         = {0300-9564},
  keyword      = {Alzheimer's disease,Blood-CSF barrier,Metals,Blood,Cerebrospinal,fluid},
  language     = {eng},
  number       = {6},
  pages        = {957--962},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer's disease},
  url          = {http://dx.doi.org/10.1007/s00702-011-0605-x},
  volume       = {118},
  year         = {2011},
}