Influence of family size and birth order on risk of cancer: a population-based study
(2011) In BMC Cancer 11.- Abstract
- Background: Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family Cancer Database to further analyze these effects. Methods: We selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth order and family size by Poisson regression adjusted for age, sex, period, region and socioeconomic status. We divided the age at diagnosis in two groups, below and over 50 years, to identify the effect of family size and birth order for different age periods. Results: Negative associations for increasing birth order were found for endometrial,... (More)
- Background: Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family Cancer Database to further analyze these effects. Methods: We selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth order and family size by Poisson regression adjusted for age, sex, period, region and socioeconomic status. We divided the age at diagnosis in two groups, below and over 50 years, to identify the effect of family size and birth order for different age periods. Results: Negative associations for increasing birth order were found for endometrial, testicular, skin, thyroid and connective tissue cancers and melanoma. In contrast, we observed positive association between birth order and lung, male and female genital cancers. Family size was associated with decreasing risk for endometrial and testicular cancers, melanoma and squamous cell carcinoma; risk was increased for leukemia and nervous system cancer. The effect of birth order decreased for lung and endometrial cancer from age at diagnosis below to over 50 years. Combined effects for birth order and family size were marginally significant for thyroid gland tumors. Especially, the relative risk for follicular thyroid gland tumors was significantly decreased for increasing birth order. Conclusion: Our findings suggest that the effect of birth order decreases from early to late adulthood for lung and endometrial cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1986116
- author
- Bevier, Melanie ; Weires, Marianne ; Thomsen, Hauke ; Sundquist, Jan LU and Hemminki, Kari LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Cancer
- volume
- 11
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000291023300001
- scopus:79955700756
- pmid:21554674
- ISSN
- 1471-2407
- DOI
- 10.1186/1471-2407-11-163
- language
- English
- LU publication?
- yes
- id
- 7d6b47c7-c62e-4d1b-98bc-44526964c1d5 (old id 1986116)
- date added to LUP
- 2016-04-01 13:23:19
- date last changed
- 2022-01-27 18:57:34
@article{7d6b47c7-c62e-4d1b-98bc-44526964c1d5,
abstract = {{Background: Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family Cancer Database to further analyze these effects. Methods: We selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth order and family size by Poisson regression adjusted for age, sex, period, region and socioeconomic status. We divided the age at diagnosis in two groups, below and over 50 years, to identify the effect of family size and birth order for different age periods. Results: Negative associations for increasing birth order were found for endometrial, testicular, skin, thyroid and connective tissue cancers and melanoma. In contrast, we observed positive association between birth order and lung, male and female genital cancers. Family size was associated with decreasing risk for endometrial and testicular cancers, melanoma and squamous cell carcinoma; risk was increased for leukemia and nervous system cancer. The effect of birth order decreased for lung and endometrial cancer from age at diagnosis below to over 50 years. Combined effects for birth order and family size were marginally significant for thyroid gland tumors. Especially, the relative risk for follicular thyroid gland tumors was significantly decreased for increasing birth order. Conclusion: Our findings suggest that the effect of birth order decreases from early to late adulthood for lung and endometrial cancer.}},
author = {{Bevier, Melanie and Weires, Marianne and Thomsen, Hauke and Sundquist, Jan and Hemminki, Kari}},
issn = {{1471-2407}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cancer}},
title = {{Influence of family size and birth order on risk of cancer: a population-based study}},
url = {{https://lup.lub.lu.se/search/files/3339992/2172502.pdf}},
doi = {{10.1186/1471-2407-11-163}},
volume = {{11}},
year = {{2011}},
}