Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.
(2010) In Journal of Clinical Densitometry 13(4). p.407-412- Abstract
- Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009... (More)
- Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1645281
- author
- Lenora, Janaka; Åkesson, Kristina LU and Gerdhem, Paul LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Duel energy x-ray absorptiometry, longitudinal follow-up, least significant change, elderly individuals, precision error.
- in
- Journal of Clinical Densitometry
- volume
- 13
- issue
- 4
- pages
- 407 - 412
- publisher
- Elsevier
- external identifiers
-
- wos:000283892400012
- pmid:20605500
- scopus:77958478634
- ISSN
- 1094-6950
- DOI
- 10.1016/j.jocd.2010.04.004
- language
- English
- LU publication?
- yes
- id
- 19da6022-d8f5-4ac0-b6e6-96a22124735c (old id 1645281)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20605500?dopt=Abstract
- date added to LUP
- 2010-08-02 10:32:43
- date last changed
- 2019-02-20 01:17:02
@article{19da6022-d8f5-4ac0-b6e6-96a22124735c,
abstract = {Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons.},
author = {Lenora, Janaka and Åkesson, Kristina and Gerdhem, Paul},
issn = {1094-6950},
keyword = {Duel energy x-ray absorptiometry,longitudinal follow-up,least significant change,elderly individuals,precision error.},
language = {eng},
number = {4},
pages = {407--412},
publisher = {Elsevier},
series = {Journal of Clinical Densitometry},
title = {Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.},
url = {http://dx.doi.org/10.1016/j.jocd.2010.04.004},
volume = {13},
year = {2010},
}