Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.
(2010) In Journal of Clinical Densitometry 13(4). p.407-412- Abstract
- Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009... (More)
- Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1645281
- author
- Lenora, Janaka ; Åkesson, Kristina LU and Gerdhem, Paul LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Duel energy x-ray absorptiometry, longitudinal follow-up, least significant change, elderly individuals, precision error.
- in
- Journal of Clinical Densitometry
- volume
- 13
- issue
- 4
- pages
- 407 - 412
- publisher
- Elsevier
- external identifiers
-
- wos:000283892400012
- pmid:20605500
- scopus:77958478634
- pmid:20605500
- ISSN
- 1094-6950
- DOI
- 10.1016/j.jocd.2010.04.004
- language
- English
- LU publication?
- yes
- id
- 19da6022-d8f5-4ac0-b6e6-96a22124735c (old id 1645281)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20605500?dopt=Abstract
- date added to LUP
- 2016-04-01 09:57:32
- date last changed
- 2025-04-04 13:51:55
@article{19da6022-d8f5-4ac0-b6e6-96a22124735c,
abstract = {{Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons.}},
author = {{Lenora, Janaka and Åkesson, Kristina and Gerdhem, Paul}},
issn = {{1094-6950}},
keywords = {{Duel energy x-ray absorptiometry; longitudinal follow-up; least significant change; elderly individuals; precision error.}},
language = {{eng}},
number = {{4}},
pages = {{407--412}},
publisher = {{Elsevier}},
series = {{Journal of Clinical Densitometry}},
title = {{Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.}},
url = {{https://lup.lub.lu.se/search/files/1424702/1687594.pdf}},
doi = {{10.1016/j.jocd.2010.04.004}},
volume = {{13}},
year = {{2010}},
}