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Clinical implications of different risk factor profiles in patients with mesenteric venous thrombosis and systemic venous thromboembolism : a population-based study

Salim, Saman LU ; Zarrouk, Moncef LU ; Elf, Johan LU ; Gottsäter, Anders LU ; Sveinsdottir, Signy LU ; Svensson, Peter LU and Acosta, Stefan LU orcid (2019) In Journal of Thrombosis and Thrombolysis
Abstract

It is unknown whether the risk factor profile for mesenteric venous thrombosis (MVT) is different from systemic venous thromboembolism (VTE). The aim of the present population-based study was to compare acquired and inherited risk factors in MVT versus VTE. Identification of all MVT patients at Skåne University Hospital between 2000 and 2015 was performed in patient records and AuriculA (Swedish anticoagulation registry). VTE patients were retrieved from the Malmö Thrombophilia Study (MATS), including 1465 consecutive unselected VTE patients between 1998 and 2008. Patients with MVT (n = 120) were younger (p < 0.001), had higher glomerular filtration rate (p < 0.001), lower smoking rate (p < 0.001), and had less often undergone... (More)

It is unknown whether the risk factor profile for mesenteric venous thrombosis (MVT) is different from systemic venous thromboembolism (VTE). The aim of the present population-based study was to compare acquired and inherited risk factors in MVT versus VTE. Identification of all MVT patients at Skåne University Hospital between 2000 and 2015 was performed in patient records and AuriculA (Swedish anticoagulation registry). VTE patients were retrieved from the Malmö Thrombophilia Study (MATS), including 1465 consecutive unselected VTE patients between 1998 and 2008. Patients with MVT (n = 120) were younger (p < 0.001), had higher glomerular filtration rate (p < 0.001), lower smoking rate (p < 0.001), and had less often undergone recent surgery (p = 0.025). The prevalence of solid cancer (19.2% in MVT versus 12.1% in VTE; p = 0.026) and intra-abdominal cancer (16.7% versus 2.3%; p < 0.001) were higher in MVT. The prevalence of factor V Leiden mutation without presence of cancer was lower in MVT compared to VTE (26.6% versus 38.9%; p = 0.031). Thirty-day mortality was higher in the MVT group (9.2% versus 0.6%; p < 0.001), but did not differ at long-term follow-up according to Kaplan–Meier analysis (p = 0.73). Patients with MVT have a higher prevalence of cancer and lower prevalence of factor V Leiden mutation than those with systemic VTE. Intra-abdominal cancer should be excluded in MVT patients, and the high prevalence of factor V Leiden mutation in patients without cancer in both groups suggests that screening for thrombophilia in patients without cancer should be considered in this population for both groups.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Factor V Leiden mutation, Mesenteric venous thrombosis, Prothrombin mutation, Thrombophilia testing, Venous thromboembolism
in
Journal of Thrombosis and Thrombolysis
publisher
Springer
external identifiers
  • scopus:85061489086
  • pmid:30756343
ISSN
0929-5305
DOI
10.1007/s11239-019-01816-x
language
English
LU publication?
yes
id
1abdc0b7-f671-40d2-b11f-e57a7c8f56ca
date added to LUP
2019-02-21 13:16:30
date last changed
2024-04-30 01:28:46
@article{1abdc0b7-f671-40d2-b11f-e57a7c8f56ca,
  abstract     = {{<p>It is unknown whether the risk factor profile for mesenteric venous thrombosis (MVT) is different from systemic venous thromboembolism (VTE). The aim of the present population-based study was to compare acquired and inherited risk factors in MVT versus VTE. Identification of all MVT patients at Skåne University Hospital between 2000 and 2015 was performed in patient records and AuriculA (Swedish anticoagulation registry). VTE patients were retrieved from the Malmö Thrombophilia Study (MATS), including 1465 consecutive unselected VTE patients between 1998 and 2008. Patients with MVT (n = 120) were younger (p &lt; 0.001), had higher glomerular filtration rate (p &lt; 0.001), lower smoking rate (p &lt; 0.001), and had less often undergone recent surgery (p = 0.025). The prevalence of solid cancer (19.2% in MVT versus 12.1% in VTE; p = 0.026) and intra-abdominal cancer (16.7% versus 2.3%; p &lt; 0.001) were higher in MVT. The prevalence of factor V Leiden mutation without presence of cancer was lower in MVT compared to VTE (26.6% versus 38.9%; p = 0.031). Thirty-day mortality was higher in the MVT group (9.2% versus 0.6%; p &lt; 0.001), but did not differ at long-term follow-up according to Kaplan–Meier analysis (p = 0.73). Patients with MVT have a higher prevalence of cancer and lower prevalence of factor V Leiden mutation than those with systemic VTE. Intra-abdominal cancer should be excluded in MVT patients, and the high prevalence of factor V Leiden mutation in patients without cancer in both groups suggests that screening for thrombophilia in patients without cancer should be considered in this population for both groups.</p>}},
  author       = {{Salim, Saman and Zarrouk, Moncef and Elf, Johan and Gottsäter, Anders and Sveinsdottir, Signy and Svensson, Peter and Acosta, Stefan}},
  issn         = {{0929-5305}},
  keywords     = {{Factor V Leiden mutation; Mesenteric venous thrombosis; Prothrombin mutation; Thrombophilia testing; Venous thromboembolism}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Springer}},
  series       = {{Journal of Thrombosis and Thrombolysis}},
  title        = {{Clinical implications of different risk factor profiles in patients with mesenteric venous thrombosis and systemic venous thromboembolism : a population-based study}},
  url          = {{http://dx.doi.org/10.1007/s11239-019-01816-x}},
  doi          = {{10.1007/s11239-019-01816-x}},
  year         = {{2019}},
}