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A prospective observational treatment study of aerococcal urinary tract infection

Oskooi, Mohammad; Sunnerhagen, Torgny LU ; Senneby, Erik LU and Rasmussen, Magnus LU (2018) In Journal of Infection 76(4). p.354-360
Abstract

Objectives: Aerococcus urinae and Aerococcus sanguinicola cause urinary tract infections (UTIs) and antibiotic treatment recommendations are solely based on in vitro findings and limited clinical experience. Our objective was to investigate the effectiveness of different treatment strategies in aerococcal UTI through a prospective observational study. Methods: Urine samples with aerococci were identified and patients were enrolled. The aerococci were subjected to Etests. Information on clinical symptoms, and the treatment given, was collected. Patients were interviewed after the conclusion of treatment to assess clinical cure and a control urine culture assessed the microbiological cure. Results: Of 31,629 urine samples, 144 grew... (More)

Objectives: Aerococcus urinae and Aerococcus sanguinicola cause urinary tract infections (UTIs) and antibiotic treatment recommendations are solely based on in vitro findings and limited clinical experience. Our objective was to investigate the effectiveness of different treatment strategies in aerococcal UTI through a prospective observational study. Methods: Urine samples with aerococci were identified and patients were enrolled. The aerococci were subjected to Etests. Information on clinical symptoms, and the treatment given, was collected. Patients were interviewed after the conclusion of treatment to assess clinical cure and a control urine culture assessed the microbiological cure. Results: Of 31,629 urine samples, 144 grew aerococci and fulfilled the inclusion criteria. 91 patients gave consent and the 72 patients with UTI were assessed for treatment outcome. 53 patients had A. urinae UTI, while 19 had A. sanguinicola UTI. Nitrofurantoin was most commonly prescribed, achieving clinical and microbiological success in 71/76% of cases of A. urinae UTI, and 42/50% of cases of A. sanguinicola UTI. Pivmecillinam achieved success in patients with A. urinae cystitis and ciprofloxacin in patients with pyelonephritis. Conclusions: Our results support that nitrofurantoin is a valid option for the treatment of cystitis caused by A. urinae.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aerococcus, Nitrofurantoin, Observational trial, Urinary tract infection
in
Journal of Infection
volume
76
issue
4
pages
354 - 360
publisher
W B Saunders
external identifiers
  • scopus:85039171630
ISSN
0163-4453
DOI
10.1016/j.jinf.2017.12.009
language
English
LU publication?
yes
id
1af8a0cb-9f21-4003-b5ef-127e51d0bb65
date added to LUP
2018-01-23 12:10:52
date last changed
2019-01-06 13:41:50
@article{1af8a0cb-9f21-4003-b5ef-127e51d0bb65,
  abstract     = {<p>Objectives: Aerococcus urinae and Aerococcus sanguinicola cause urinary tract infections (UTIs) and antibiotic treatment recommendations are solely based on in vitro findings and limited clinical experience. Our objective was to investigate the effectiveness of different treatment strategies in aerococcal UTI through a prospective observational study. Methods: Urine samples with aerococci were identified and patients were enrolled. The aerococci were subjected to Etests. Information on clinical symptoms, and the treatment given, was collected. Patients were interviewed after the conclusion of treatment to assess clinical cure and a control urine culture assessed the microbiological cure. Results: Of 31,629 urine samples, 144 grew aerococci and fulfilled the inclusion criteria. 91 patients gave consent and the 72 patients with UTI were assessed for treatment outcome. 53 patients had A. urinae UTI, while 19 had A. sanguinicola UTI. Nitrofurantoin was most commonly prescribed, achieving clinical and microbiological success in 71/76% of cases of A. urinae UTI, and 42/50% of cases of A. sanguinicola UTI. Pivmecillinam achieved success in patients with A. urinae cystitis and ciprofloxacin in patients with pyelonephritis. Conclusions: Our results support that nitrofurantoin is a valid option for the treatment of cystitis caused by A. urinae.</p>},
  author       = {Oskooi, Mohammad and Sunnerhagen, Torgny and Senneby, Erik and Rasmussen, Magnus},
  issn         = {0163-4453},
  keyword      = {Aerococcus,Nitrofurantoin,Observational trial,Urinary tract infection},
  language     = {eng},
  number       = {4},
  pages        = {354--360},
  publisher    = {W B Saunders},
  series       = {Journal of Infection},
  title        = {A prospective observational treatment study of aerococcal urinary tract infection},
  url          = {http://dx.doi.org/10.1016/j.jinf.2017.12.009},
  volume       = {76},
  year         = {2018},
}