Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease
Dreja, Julia ; Ekberg, Olle LU ; Leander, Peter LU ; Månsson, Sven LU
and Ohlsson, Bodil
LU
(2020)
In Neurogastroenterology and Motility
32(10).
- Abstract
Background: Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice. Methods: Healthy volunteers and all consecutive patients referred to MRE during a 2-year period were asked to participate and complete the Irritable Bowel Syndrome-Symptom Severity Scale (IBS-SSS) to assess gastrointestinal symptoms. Medical records were scrutinized, and motility indices (MIs) were calculated from MR images. Key Results: Twenty-two healthy controls and 134 examinations with CD were included (inclusion rate: 76.3%). Patients with CD had increased mural thickness of the terminal ileum,... (More)
Background: Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice. Methods: Healthy volunteers and all consecutive patients referred to MRE during a 2-year period were asked to participate and complete the Irritable Bowel Syndrome-Symptom Severity Scale (IBS-SSS) to assess gastrointestinal symptoms. Medical records were scrutinized, and motility indices (MIs) were calculated from MR images. Key Results: Twenty-two healthy controls and 134 examinations with CD were included (inclusion rate: 76.3%). Patients with CD had increased mural thickness of the terminal ileum, increased fecal calprotectin, and more symptoms than controls. Patients with active CD had increased mural thickness of ileum and terminal ileum, higher MR activity indices, and signs of inflammation in laboratory analyses, but similar symptoms, compared with inactive disease. After exclusion of sole colon disease (n = 13), MI inversely correlated with mural thickness in terminal ileum, and MI was lower in active disease versus controls in ileum (P =.019) and terminal ileum (P =.005), and versus inactive disease in terminal ileum (P =.044). The area under the curve of MI in terminal ileum was 0.736 for active CD against healthy controls (P =.002) and 0.682 for active against inactive CD (P =.001). MIs were similar in controls and inactive CD. Conclusions and Interferences: MI reflects inflammatory activity in the intestine. Alterations in MI did not explain symptomatology in inactive CD, without measurable inflammatory parameters in morphology or laboratory analyses.
(Less)
- author
- Dreja, Julia
; Ekberg, Olle
LU
; Leander, Peter
LU
; Månsson, Sven
LU
and Ohlsson, Bodil
LU
- organization
- publishing date
- 2020-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Crohn's disease, magnetic resonance enterography, motility index
- in
- Neurogastroenterology and Motility
- volume
- 32
- issue
- 10
- article number
- e13909
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32469111
- scopus:85085499803
- ISSN
- 1350-1925
- DOI
- 10.1111/nmo.13909
- language
- English
- LU publication?
- yes
- id
- 1bafe102-ac56-4001-9940-7aeded0570bf
- date added to LUP
- 2020-06-25 09:36:50
- date last changed
- 2024-03-04 22:03:23
@article{1bafe102-ac56-4001-9940-7aeded0570bf,
abstract = {{<p>Background: Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice. Methods: Healthy volunteers and all consecutive patients referred to MRE during a 2-year period were asked to participate and complete the Irritable Bowel Syndrome-Symptom Severity Scale (IBS-SSS) to assess gastrointestinal symptoms. Medical records were scrutinized, and motility indices (MIs) were calculated from MR images. Key Results: Twenty-two healthy controls and 134 examinations with CD were included (inclusion rate: 76.3%). Patients with CD had increased mural thickness of the terminal ileum, increased fecal calprotectin, and more symptoms than controls. Patients with active CD had increased mural thickness of ileum and terminal ileum, higher MR activity indices, and signs of inflammation in laboratory analyses, but similar symptoms, compared with inactive disease. After exclusion of sole colon disease (n = 13), MI inversely correlated with mural thickness in terminal ileum, and MI was lower in active disease versus controls in ileum (P =.019) and terminal ileum (P =.005), and versus inactive disease in terminal ileum (P =.044). The area under the curve of MI in terminal ileum was 0.736 for active CD against healthy controls (P =.002) and 0.682 for active against inactive CD (P =.001). MIs were similar in controls and inactive CD. Conclusions and Interferences: MI reflects inflammatory activity in the intestine. Alterations in MI did not explain symptomatology in inactive CD, without measurable inflammatory parameters in morphology or laboratory analyses.</p>}},
author = {{Dreja, Julia and Ekberg, Olle and Leander, Peter and Månsson, Sven and Ohlsson, Bodil}},
issn = {{1350-1925}},
keywords = {{Crohn's disease; magnetic resonance enterography; motility index}},
language = {{eng}},
number = {{10}},
publisher = {{Wiley-Blackwell}},
series = {{Neurogastroenterology and Motility}},
title = {{Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease}},
url = {{http://dx.doi.org/10.1111/nmo.13909}},
doi = {{10.1111/nmo.13909}},
volume = {{32}},
year = {{2020}},
}