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The use of ultra-high frequency ultrasound in identifying aganglionosis in Hirschsprung’s disease

Hawez, Tebin LU orcid ; Evertsson, Maria LU ; Erlöv, Tobias LU ; Hagelsteen, Kristine LU orcid ; Tofft, Louise LU orcid ; Jansson, Tomas LU ; Cinthio, Magnus LU orcid ; Granéli, Christina LU and Stenström, Pernilla LU orcid (2025) In Scientific Reports 15(1).
Abstract

To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel specimens of 23 children operated on for rectosigmoid Hirschsprung’s disease were examined ex vivo using the Vevo MD UHF70 (MHz) probe delivering 30 μm-resolution. In ganglionic versus aganglionic bowel in UHFUS images, patients serving their own controls, the thickness of the muscularis interna was thicker (0.540 vs. 0.322 mm; p < 0.001; CI 0.148–0.289), the ratio of thickness of muscularis... (More)

To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel specimens of 23 children operated on for rectosigmoid Hirschsprung’s disease were examined ex vivo using the Vevo MD UHF70 (MHz) probe delivering 30 μm-resolution. In ganglionic versus aganglionic bowel in UHFUS images, patients serving their own controls, the thickness of the muscularis interna was thicker (0.540 vs. 0.322 mm; p < 0.001; CI 0.148–0.289), the ratio of thickness of muscularis interna/muscularis externa was greater (1.194 vs. 0.846; p = 0.011; CI 0.085–0.596), and the submucosa’s echogenicity was lower (100.0 vs. 115.3; p < 0.001; CI − 21.8 to − 8.7). The results indicate that delineation between aganglionosis and ganglionosis can be undertaken by UHFUS, underlining important research for precise diagnostics with UHFUS in vivo.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
15
issue
1
article number
15124
publisher
Nature Publishing Group
external identifiers
  • scopus:105003867378
  • pmid:40301537
ISSN
2045-2322
DOI
10.1038/s41598-025-99897-7
language
English
LU publication?
yes
id
1bf8b88a-01f9-4b28-89d2-78874cab5c3f
date added to LUP
2025-07-15 09:06:11
date last changed
2025-07-15 09:07:21
@article{1bf8b88a-01f9-4b28-89d2-78874cab5c3f,
  abstract     = {{<p>To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel specimens of 23 children operated on for rectosigmoid Hirschsprung’s disease were examined ex vivo using the Vevo MD UHF70 (MHz) probe delivering 30 μm-resolution. In ganglionic versus aganglionic bowel in UHFUS images, patients serving their own controls, the thickness of the muscularis interna was thicker (0.540 vs. 0.322 mm; p &lt; 0.001; CI 0.148–0.289), the ratio of thickness of muscularis interna/muscularis externa was greater (1.194 vs. 0.846; p = 0.011; CI 0.085–0.596), and the submucosa’s echogenicity was lower (100.0 vs. 115.3; p &lt; 0.001; CI − 21.8 to − 8.7). The results indicate that delineation between aganglionosis and ganglionosis can be undertaken by UHFUS, underlining important research for precise diagnostics with UHFUS in vivo.</p>}},
  author       = {{Hawez, Tebin and Evertsson, Maria and Erlöv, Tobias and Hagelsteen, Kristine and Tofft, Louise and Jansson, Tomas and Cinthio, Magnus and Granéli, Christina and Stenström, Pernilla}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{The use of ultra-high frequency ultrasound in identifying aganglionosis in Hirschsprung’s disease}},
  url          = {{http://dx.doi.org/10.1038/s41598-025-99897-7}},
  doi          = {{10.1038/s41598-025-99897-7}},
  volume       = {{15}},
  year         = {{2025}},
}