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Liver resection of noncolorectal secondaries

Lindell, Gert LU ; Ohlsson, Björn LU ; Saarela, Arto ; Andersson, Roland LU and Tranberg, Karl Göran LU (1998) In Journal of Surgical Oncology 69(2). p.66-70
Abstract

Background and Objectives: Hepatic resection of noncolorectal metastases appears to be performed with increasing frequency. Reported experience is limited and indications are controversial. Methods: Retrospective review of curative hepatic resection in 32 patients (median age 58 years) during 1970- 1995. The primary tumor was a carcinoid in seven patients, other endocrine tumor in five patients, malignant melanoma in three patients, stomach cancer in three patients, exocrine pancreatic cancer in two patients, gynecological cancer in two patients, sarcoma in two patients, and miscellaneous in eight patients. Seven patients (22%) had bilobar disease and 12 patients (38%) had extrahepatic growth. Results: Median survival was 32 months, and... (More)

Background and Objectives: Hepatic resection of noncolorectal metastases appears to be performed with increasing frequency. Reported experience is limited and indications are controversial. Methods: Retrospective review of curative hepatic resection in 32 patients (median age 58 years) during 1970- 1995. The primary tumor was a carcinoid in seven patients, other endocrine tumor in five patients, malignant melanoma in three patients, stomach cancer in three patients, exocrine pancreatic cancer in two patients, gynecological cancer in two patients, sarcoma in two patients, and miscellaneous in eight patients. Seven patients (22%) had bilobar disease and 12 patients (38%) had extrahepatic growth. Results: Median survival was 32 months, and 5-year actuarial survival rate was 36% (including operative mortality). Median survival in the endocrine (n = 12) and nonendocrine (n = 20) groups was 72 and 18 months, respectively (corresponding 5-year survival rates were 56 and 25%) (P = 0.16). Prognostic factors could not be established in either group. It is, however, noteworthy that no patient with nonendocrine secondaries and more than one liver tumor or extrahepatic disease survived for 5 years. Major complications were seen in eight patients (25%), including three postoperative deaths (operative mortality 9%) occurring during the first 5 years of the study period. Conclusions: Hepatic resection of metastases from endocrine primary tumors was followed by long-term survival in a substantial proportion of patients. Long-term survival for patients with nonendocrine tumors was observed only when there was a single liver tumor and no extrahepatic growth. Further experience is needed for definition of resection criteria.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endocrine, Hepatic resection, Liver metastases, Noncolorectal
in
Journal of Surgical Oncology
volume
69
issue
2
pages
5 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0031793879
ISSN
0022-4790
DOI
10.1002/(SICI)1096-9098(199810)69:2<66::AID-JSO4>3.0.CO;2-G
language
English
LU publication?
yes
id
1c3943a8-0ff7-466e-a2ce-ce00bf87a32f
date added to LUP
2019-06-15 16:54:44
date last changed
2020-04-07 05:29:22
@article{1c3943a8-0ff7-466e-a2ce-ce00bf87a32f,
  abstract     = {<p>Background and Objectives: Hepatic resection of noncolorectal metastases appears to be performed with increasing frequency. Reported experience is limited and indications are controversial. Methods: Retrospective review of curative hepatic resection in 32 patients (median age 58 years) during 1970- 1995. The primary tumor was a carcinoid in seven patients, other endocrine tumor in five patients, malignant melanoma in three patients, stomach cancer in three patients, exocrine pancreatic cancer in two patients, gynecological cancer in two patients, sarcoma in two patients, and miscellaneous in eight patients. Seven patients (22%) had bilobar disease and 12 patients (38%) had extrahepatic growth. Results: Median survival was 32 months, and 5-year actuarial survival rate was 36% (including operative mortality). Median survival in the endocrine (n = 12) and nonendocrine (n = 20) groups was 72 and 18 months, respectively (corresponding 5-year survival rates were 56 and 25%) (P = 0.16). Prognostic factors could not be established in either group. It is, however, noteworthy that no patient with nonendocrine secondaries and more than one liver tumor or extrahepatic disease survived for 5 years. Major complications were seen in eight patients (25%), including three postoperative deaths (operative mortality 9%) occurring during the first 5 years of the study period. Conclusions: Hepatic resection of metastases from endocrine primary tumors was followed by long-term survival in a substantial proportion of patients. Long-term survival for patients with nonendocrine tumors was observed only when there was a single liver tumor and no extrahepatic growth. Further experience is needed for definition of resection criteria.</p>},
  author       = {Lindell, Gert and Ohlsson, Björn and Saarela, Arto and Andersson, Roland and Tranberg, Karl Göran},
  issn         = {0022-4790},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {66--70},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Surgical Oncology},
  title        = {Liver resection of noncolorectal secondaries},
  url          = {http://dx.doi.org/10.1002/(SICI)1096-9098(199810)69:2<66::AID-JSO4>3.0.CO;2-G},
  doi          = {10.1002/(SICI)1096-9098(199810)69:2<66::AID-JSO4>3.0.CO;2-G},
  volume       = {69},
  year         = {1998},
}