Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer

Lehtinen, Tuomas ; Zhang, Luayo ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Waterboer, Tim ; Lehtinen, Matti and Hemminki, Kari LU (2025) In Cancer Reports 8(9).
Abstract

Introduction: Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database. Methods: The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls. Results: The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and... (More)

Introduction: Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database. Methods: The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls. Results: The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002–2015, the RR peaked at 5.35 (95% CI 2.21–13.0) in TSCC/BOTSCC cases diagnosed at age < 50 years. In husbands of women with CIS, the RR for TSCC/BOTSCC was 2-fold irrespective of time period. Conclusions: Clustering of increased HPV-associated invasive cancer risk in spouses appears to be calendar-time dependent. This introduces a new perspective in cancer science: an increase of familial HPV-associated cancer risk in spouses.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
familial cancer, head and neck cancer, viral infection, viral oncology
in
Cancer Reports
volume
8
issue
9
article number
e70333
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:40877205
  • scopus:105014622347
ISSN
2573-8348
DOI
10.1002/cnr2.70333
language
English
LU publication?
yes
id
1c4ff785-cf91-4c70-bee5-77c27301da5a
date added to LUP
2025-10-16 13:09:16
date last changed
2025-11-13 15:11:30
@article{1c4ff785-cf91-4c70-bee5-77c27301da5a,
  abstract     = {{<p>Introduction: Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database. Methods: The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls. Results: The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002–2015, the RR peaked at 5.35 (95% CI 2.21–13.0) in TSCC/BOTSCC cases diagnosed at age &lt; 50 years. In husbands of women with CIS, the RR for TSCC/BOTSCC was 2-fold irrespective of time period. Conclusions: Clustering of increased HPV-associated invasive cancer risk in spouses appears to be calendar-time dependent. This introduces a new perspective in cancer science: an increase of familial HPV-associated cancer risk in spouses.</p>}},
  author       = {{Lehtinen, Tuomas and Zhang, Luayo and Sundquist, Kristina and Sundquist, Jan and Waterboer, Tim and Lehtinen, Matti and Hemminki, Kari}},
  issn         = {{2573-8348}},
  keywords     = {{familial cancer; head and neck cancer; viral infection; viral oncology}},
  language     = {{eng}},
  number       = {{9}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Cancer Reports}},
  title        = {{Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer}},
  url          = {{http://dx.doi.org/10.1002/cnr2.70333}},
  doi          = {{10.1002/cnr2.70333}},
  volume       = {{8}},
  year         = {{2025}},
}